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All Journal Jurnal Biologi Tropis
Raditya Bayu Farizil Akhyar
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Journal : Jurnal Biologi Tropis

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Inguinal Hernia: Diagnosis and Management Nabila Aisyah Putri; Nur Feby Febiana Agistany; Raditya Bayu Farizil Akhyar; Salsabila Chauna; Wardha Novia Annisa; Zikrul Haikal
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5721

Abstract

The inguinal hernia is the subcutaneous part of the peritoneum containing the abdominal viscera that exits through the inguinal canal or directly through the abdominal wall. Most patients do not realize they have an inguinal hernia until swelling arises in the thigh fold area or pain in the groin area. The purpose of this literature review is to provide an update regarding the diagnosis and management of inguinal hernias. The diagnosis of an inguinal hernia is largely based on the history and physical examination, whereas imaging is rarely performed unless there is a certain suspicion. Surgical management can be performed on patients with symptoms, while asymptomatic patients can be subjected to conservative therapy.
Protein S Deficiency and The Mechanism of Protein S in Hemostasis and Atherosclerosis Nur Feby Febiana Agistany; Ananda Karunia Ramadhan; Dira Kurnia Rizki; Raditya Bayu Farizil Akhyar; Ilsa Hunaifi
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5565

Abstract

Protein S (PS) is Vitamin K dependant protein which plays a role in regulating the blood clotting process in the body. Protein S deficiency is explained as a condition characterized by reduced levels of protein S in the serum so that it makes the blood clot too easily. The purpose of this literature review is to give an update of protein S defficiency and the mechanism of protein s in hemostasis and atherosclerosis based on publish literature reference from various database. Protein S plays important role in hemostasis by regulating blood cloth process in the initiation phase of the extrinsic pathway as a TFPI cofactor or in the propagation phase, namely as an APC cofactor and independent activity of TFPIα and APC. Protein S deficiency is known to be associated with the occurrence of atherosclerosis via the Tyro3-Axl-Mer (TAM) receptor. The main clinical manifestations of the majority of patients with heterozygous mutations in the protein S (PROS1) gene are deep vein thrombosis (DVT) and pulmonary embolism that precipitate by VTE. Administration of anticoagulant drugs such as heparin in the form of low-molecular-weight heparin (LMWH) or unfractionated heparin, vitamin K antagonists (VKA), namely warfarin, or direct oral anticoagulants (DOACs) can be selected as a management of protein S deficiency with VTE. Protein S has a central role in the coagulation prosses and its deficiency associated with atherosclerotic conditions.
Co-Authors Ananda Karunia Ramadhan Dira Kurnia Rizki Ilsa Hunaifi Nabila Aisyah Putri Nur Feby Febiana Agistany Nur Feby Febiana Agistany Salsabila Chauna Wardha Novia Annisa Zikrul Haikal