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All Journal Indonesian Journal of Tropical and Infectious Disease Universa Medicina MITRA: Jurnal Pemberdayaan Masyarakat Cermin Dunia Kedokteran
Wijaya, Meiliyana
Departemen Parasitologi, Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia
Humanities Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uncontrolled blood sugar tends to increase prevalence of dermatomycosis in diabetic type 2 patients Surja, Sem Samuel; Hermawan, Melyawati; Wijaya, Meiliyana; Pramanta, Pramanta; Yolanda, Hanna
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (729.675 KB) | DOI: 10.18051/UnivMed.2018.v37.188-194

Abstract

Background The prevalence of type 2 diabetes mellitus (DM) is increasing. Diabetic patients have a higher risk of getting dermatomycosis. Dermatomycoses, although a common health problem amongst DM, is often misdiagnosed and consequently undertreated. Studies on the association between dermatomycosis and type 2 diabetes are lacking, especially in Indonesia. Therefore, the aim of this study was to determine the prevalence, etiology, and association of dermatomycosis with diabetic control of type 2 DM. MethodsA cross-sectional study was performed involving 87 subjects with type 2 DM. Demographic and clinical data, including age, sex, and blood glucose level, were collected. If a dermatomycosis lesion was found, a specimen would be taken for identification. Determination of serum glucose level was conducted using Roche c111 analyzer®. Statistical analysis was performed with the chi-square test and Kolmogorov-Smirnov two-independent sample test.ResultsSeventeen (19.55%) subjects had dermatomycosis. The predominant age group affected was 51 - 60 years (42.4%). The number of clinically apparent dermatomycosis was greater in the uncontrolled than in the controlled blood sugar group, but the difference was statistically not significant (p > 0.05). The lesions were mostly found on the nails (74%) and the most common etiology was candida (50%) followed by dermatophyte (25%) and non-dermatophyte molds (25%). ConclusionUncontrolled blood sugar tends to increase the risk of dermatomycosis in type 2 DM patients. Fungal skin infections are common in type-2 DM patients, especially in those with poor glycemic control.
Meningitis Kriptokokus pada Penderita HIV Wijaya, Meiliyana
Cermin Dunia Kedokteran Vol 48, No 1 (2021): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.69 KB) | DOI: 10.55175/cdk.v48i1.1256

Abstract

Meningitis kriptokokus (MK) merupakan salah satu bentuk infeksi oportunistik pada penderita HIV yang memiliki tingkat mortalitas tinggi. Infeksi jamur ini didapat dari inhalasi spora Cryptococcus yang ada di alam dan selanjutnya berkolonisasi di paru. Pada individu yang mengalami penurunan imunitas seluler seperti penderita HIV, jamur ini dapat berdiseminasi secara hematogen terutama ke sistem saraf pusat. Saat ini, diagnosis pasti kriptokokosis dapat mengandalkan hasil tes antigen Cryptococcus dari cairan serebrospinal dan darah. Prinsip pemberian antijamur pada pasien MK dengan HIV terdiri dari 3 fase, yakni: induksi, konsolidasi, dan pemeliharaan. Selain itu, perlu penundaan pemberian obat antiretroviral saat pemberian terapi antijamur MK.Cryptococcal meningitis (CM) is an opportunistic infection in people with HIV, with a high mortality rate. This fungus infection is acquired from inhalation of Cryptococcus spores that exist in nature and then colonizes in the lungs. In individuals with decreased cellular immunity such as HIV, this fungus can cause hematogenous dissemination primarily to the central nervous system. Currently, definitive diagnosis of cryptococcosis can rely on the results of the Cryptococcus antigens test from cerebrospinal fluid and blood. The principle of antifungal administration in CM patients with HIV consists of 3 phases: induction, consolidation, and maintenance. It is also necessary to delay the administration of antiretroviral drugs while administering CM antifungal therapy.
Mukormikosis Rino-Orbito-Serebral pada Diabetes Melitus Mujono, Aivi; Lukito, Elizabeth Feloni; Wijaya, Meiliyana
Cermin Dunia Kedokteran Vol 49, No 2 (2022): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (18.667 KB) | DOI: 10.55175/cdk.v49i2.1727

Abstract

Mukormikosis rino-orbito-serebral (ROS) adalah penyakit angioinvasif akibat infeksi jamur Mucorales yang sering ditemukan pada pasien diabetes melitus (DM). Penyakit ini memiliki gambaran khas jaringan nekrotik kehitaman disebut eschar, sehingga disebut juga infeksi “jamur hitam”.Tingkat mortalitas penyakit ini tinggi terutama jika diagnosis dan tata laksana terlambat. Patogenesis mukormikosis ROS pada pasien DM antara lain: interaksi reseptor sel epitel dengan protein jamur, kadar besi bebas dalam darah, dan penurunan imunitas seluler. Diagnosis berdasarkan gambaran klinis dengan faktor risiko, identifikasi jamur, dan pencitraan. Pemeriksaan histopatologis dari jaringan biopsi dapat dikonfirmasi dengan hasil kultur. Tata laksana mukormikosis ROS pada penderita DM meliputi kombinasi debridemen, pemberian antijamur, dan mengatasi kondisi hiperglikemia.
Histoplasmosis: diagnostic and therapeutic aspect Meiliyana Wijaya; Robiatul Adawiyah; Retno Wahyuningsih
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 2 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i2.25448

Abstract

Histoplasmosis has been reported since 1932 in various regions in Indonesia. This disease is caused by thermally dimorphic fungus Histoplasma capsulatum var. capsulatum which is experiencing an increasing incidence worldwide. Human infection occurs when spores in soil contaminated with bird and bat droppings are inhaled and change to form yeast in the lungs. The majority of these forms of infection are mild and can heal on their own, but if large numbers of spores/ inoculum are inhaled, or the host is immunosuppressed, serious lung disease and even dissemination may occur with a high mortality rate. The diagnosis can be made by combining clinical symptoms with laboratory test results. Conventional laboratory methods such as direct examination or histopathology and culture are the gold standards for histoplasmosis diagnosis. The weakness of culture is the nature of H. capsulatum as a slow grower fungus that takes 4-6 weeks to grow. In addition, laboratory tests can be carried out with antibody detection or antigen detection. Antigen detection is more benefi cial for hosts with immunosuppression or acute form, while antibody detection is more important in the chronic form of the diseases. Molecular-based assays have high specifi city but are not yet available commercially and are more widely used for culture identifi cation to confi rm the species of H. capsulatum. Histoplasmosis therapy usually begins with the administration of amphotericin B for around two weeks, followed by maintenance with itraconazole for 6 - 9 months duration. A careful history of possible exposure and the appropriate laboratory diagnostic approach is essential to provide appropriate therapy.
Educational Efforts to Improve Public Awareness about Greening and Healthy Lifestyle in Urban Areas Shereen Aprillia; Jolene Budiono; Meiliyana Wijaya
MITRA: Jurnal Pemberdayaan Masyarakat Vol 6 No 1 (2022): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v6i1.2947

Abstract

Public awareness and concern about greening and healthy lifestyles in preserving the environment and improving health status are crucial despite the covid-19 pandemic. One approach to deal with this issue is by spreading the information and taking promotive actions which aim to increase public awareness of the importance of greening and healthy lifestyles in their daily lives. Various online educational activities for communities are needed to increase their knowledge and concern. In this regard, the Daerah Binaan (DABIN) unit and the Hazard Analysis and Critical Control Point (HACCP) of the Faculty of Medicine and Health Sciences at Atma Jaya Catholic University of Indonesia held a SEHATI challenge and an educational seminar "Evergreen: Go Green, Go Healthy." One of the topics raised through this online seminar was "Urban Farming in the Pandemic Period: Economical and Ecological," which discusses various benefits of growing hydroponic vegetables. In addition, the topic of promoting a healthy lifestyle includes the proper processing of fresh vegetables to avoid parasitic contamination and a healthy breakfast with the consumption of probiotics. As many as nine and 198 people attended the challenge competition and seminar. A pre-test and a post-test were held before and after the seminar to determine the participants' knowledge. The result showed that the participants' knowledge increased between 15% to 38%. The efforts to deliver periodic education about greening and healthy lifestyles action will continue to be carried out by DABIN and HACCP. These efforts aim to improve public awareness about the importance of this topic, reduce global warming, and improve the health status of an area.
Meningitis Kriptokokus pada Penderita HIV Meiliyana Wijaya
Cermin Dunia Kedokteran Vol 48, No 1 (2021): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i1.1256

Abstract

Meningitis kriptokokus (MK) merupakan salah satu bentuk infeksi oportunistik pada penderita HIV yang memiliki tingkat mortalitas tinggi. Infeksi jamur ini didapat dari inhalasi spora Cryptococcus yang ada di alam dan selanjutnya berkolonisasi di paru. Pada individu yang mengalami penurunan imunitas seluler seperti penderita HIV, jamur ini dapat berdiseminasi secara hematogen terutama ke sistem saraf pusat. Saat ini, diagnosis pasti kriptokokosis dapat mengandalkan hasil tes antigen Cryptococcus dari cairan serebrospinal dan darah. Prinsip pemberian antijamur pada pasien MK dengan HIV terdiri dari 3 fase, yakni: induksi, konsolidasi, dan pemeliharaan. Selain itu, perlu penundaan pemberian obat antiretroviral saat pemberian terapi antijamur MK.Cryptococcal meningitis (CM) is an opportunistic infection in people with HIV, with a high mortality rate. This fungus infection is acquired from inhalation of Cryptococcus spores that exist in nature and then colonizes in the lungs. In individuals with decreased cellular immunity such as HIV, this fungus can cause hematogenous dissemination primarily to the central nervous system. Currently, definitive diagnosis of cryptococcosis can rely on the results of the Cryptococcus antigens test from cerebrospinal fluid and blood. The principle of antifungal administration in CM patients with HIV consists of 3 phases: induction, consolidation, and maintenance. It is also necessary to delay the administration of antiretroviral drugs while administering CM antifungal therapy.
Mukormikosis Rino-Orbito-Serebral pada Diabetes Melitus Aivi Mujono; Elizabeth Feloni Lukito; Meiliyana Wijaya
Cermin Dunia Kedokteran Vol 49, No 2 (2022): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i2.1741

Abstract

Mukormikosis rino-orbito-serebral (ROS) adalah penyakit angioinvasif akibat infeksi jamur Mucorales yang sering ditemukan pada pasien diabetes melitus (DM). Penyakit ini memiliki gambaran khas jaringan nekrotik kehitaman disebut eschar, sehingga disebut juga infeksi “jamur hitam”. Tingkat mortalitas penyakit ini tinggi terutama jika diagnosis dan tata laksana terlambat. Patogenesis mukormikosis ROS pada pasien DM antara lain: interaksi reseptor sel epitel dengan protein jamur, kadar besi bebas dalam darah, dan penurunan imunitas seluler. Diagnosis berdasarkan gambaran klinis dengan faktor risiko, identifikasi jamur, dan pencitraan. Pemeriksaan histopatologis dari jaringan biopsi dapat dikonfirmasi dengan hasil kultur. Tata laksana mukormikosis ROS pada penderita DM meliputi kombinasi debridemen, pemberian antijamur, dan mengatasi kondisi hiperglikemia. Rhino-orbital-cerebral mucormycosis (ROCM) is an angioinvasive disease caused by Mucorales fungal infection; it is common in diabetes mellitus (DM) patients. The disease has a characteristic feature of black necrotic appearance called eschar, thus also called as “black fungus” infection.The mortality rate of this disease is high, especially in delayed diagnosis and treatment. The pathogenesis of ROCM in diabetic patients includes the interaction of epithelial cell receptors with fungal proteins, free iron blood levels, and decreased cellular immunity. Diagnosis is based onclinical features, supporting risk factors, fungus identification, and imaging. Histopathological examination on biopsy tissue confirmed by culture can establish the diagnosis. Management includes a combination of surgical debridement, antifungals, and glycemia control.
Meningitis Kriptokokus pada Penderita HIV Meiliyana Wijaya
Cermin Dunia Kedokteran Vol 48 No 1 (2021): Infeksi COVID-19
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i1.25

Abstract

Meningitis kriptokokus (MK) merupakan salah satu bentuk infeksi oportunistik pada penderita HIV yang memiliki tingkat mortalitas tinggi. Infeksi jamur ini didapat dari inhalasi spora Cryptococcus yang ada di alam dan selanjutnya berkolonisasi di paru. Pada individu yang mengalami penurunan imunitas seluler seperti penderita HIV, jamur ini dapat berdiseminasi secara hematogen terutama ke sistem saraf pusat. Saat ini, diagnosis pasti kriptokokosis dapat mengandalkan hasil tes antigen Cryptococcus dari cairan serebrospinal dan darah. Prinsip pemberian antijamur pada pasien MK dengan HIV terdiri dari 3 fase, yakni: induksi, konsolidasi, dan pemeliharaan. Selain itu, perlu penundaan pemberian obat antiretroviral saat pemberian terapi antijamur MK. Cryptococcal meningitis (CM) is an opportunistic infection in people with HIV, with a high mortality rate. This fungus infection is acquired from inhalation of Cryptococcus spores that exist in nature and then colonizes in the lungs. In individuals with decreased cellular immunity such as HIV, this fungus can cause hematogenous dissemination primarily to the central nervous system. Currently, definitive diagnosis of cryptococcosis can rely on the results of the Cryptococcus antigens test from cerebrospinal fluid and blood. The principle of antifungal administration in CM patients with HIV consists of 3 phases: induction, consolidation, and maintenance. It is also necessary to delay the administration of antiretroviral drugs while administering CM antifungal therapy.
Mukormikosis Rino-Orbito-Serebral pada Diabetes Melitus Meiliyana Wijaya; Aivi Mujono; Elizabeth Feloni Lukito
Cermin Dunia Kedokteran Vol 49 No 2 (2022): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i2.194

Abstract

Mukormikosis rino-orbito-serebral (ROS) adalah penyakit angioinvasif akibat infeksi jamur Mucorales yang sering ditemukan pada pasien diabetes melitus (DM). Penyakit ini memiliki gambaran khas jaringan nekrotik kehitaman disebut eschar, sehingga disebut juga infeksi “jamur hitam”. Tingkat mortalitas penyakit ini tinggi terutama jika diagnosis dan tata laksana terlambat. Patogenesis mukormikosis ROS pada pasien DM antara lain: interaksi reseptor sel epitel dengan protein jamur, kadar besi bebas dalam darah, dan penurunan imunitas seluler. Diagnosis berdasarkan gambaran klinis dengan faktor risiko, identifikasi jamur, dan pencitraan. Pemeriksaan histopatologis dari jaringan biopsi dapat dikonfirmasi dengan hasil kultur. Tata laksana mukormikosis ROS pada penderita DM meliputi kombinasi debridemen, pemberian antijamur, dan mengatasi kondisi hiperglikemia. Rhino-orbital-cerebral mucormycosis (ROCM) is an angioinvasive disease caused by Mucorales fungal infection; it is common in diabetes mellitus (DM) patients. The disease has a characteristic feature of black necrotic appearance called eschar, thus also called as “black fungus” infection. The mortality rate of this disease is high, especially in delayed diagnosis and treatment. The pathogenesis of ROCM in diabetic patients includes the interaction of epithelial cell receptors with fungal proteins, free iron blood levels, and decreased cellular immunity. Diagnosis is based on clinical features, supporting risk factors, fungus identification, and imaging. Histopathological examination on biopsy tissue confirmed by culture can establish the diagnosis. Management includes a combination of surgical debridement, antifungals, and glycemia control.
Co-Authors Aivi Mujono Elizabeth Feloni Lukito Hanna Yolanda Hermawan, Melyawati Jamhari Jamhari Jolene Budiono Lukito, Elizabeth Feloni Mujono, Aivi Pramanta, Pramanta Retno Wahyuningsih Sem Samuel Surja Shereen Aprillia