The purpose of this study was to analyze the effect of cash flow, profitability and leverage on financial distress, either partially or simultaneously. Secondary data collected from food and beverage companies listed on the Indonesia Stock Exchange for the 2017-2021 period and journals from previous researchers. The method used is a quantitative descriptive method. The sample was determined based on the purposive sampling method, as many as 65 samples of financial statements. The data used in this research is panel data (pooled data) which is a combination of time series data and cross section data. The data analysis method used in this study is the random effect model processed using Eviews 10. The results of this partial study indicate that Cash Flow (AK) has a positive and significant effect on financial distress (FD), Profitability (ROA) has a negative effect and significant to financial distress (FD), Leverage (DAR) has a negative and significant effect on financial distress (FD), Cash Flow (AK), Profit (ROA), and Leverage (DAR) simultaneously have a significant effect on financial distress (FD). This is because the value of Prob. (F-statistic) 0.000022 is smaller than 0.05, and Fstatistic is greater than Ftable (22.24587> 2.76), with an effect value of 49.8973% while the remaining 50.1027% can be explained using other variables which were not examined in this study. Keywords: Cash Flow, Profitability, Leverage, and Financial Distress