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All Journal Global Medical and Health Communication
Sri Utami
Faculty of Medicine, Universitas YARSI, Central Jakarta
Dentistry Health Professions Immunology & microbiology Nursing Public Health

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Cytotoxicity of Combination Doxorubicin and Garcinia picrorrhiza Fruit Extract on Fibroblast Cell Sri Utami; Susi Endrini; Lilian Batubara; Nunung Ainur Rahmah; Irfan Syarif; Said Nafik; Betharie Cendera Arrahmani; Agung Novianto; Hanna Sari Widya Kusuma; Wahyu Widowati
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10985

Abstract

Combining chemotherapeutic agents such as doxorubicin with herbal products or other compounds that can enhance cytotoxicity without side effects is required. Thus, we aimed to observe the cytotoxicity of doxorubicin and sesoot (Garcinia picrorrhiza) fruit ethanolic extract (GpKar) on human fibroblast cells, BJ. This study used a post-test-only control randomized group design with n=3 and a number group of 5. The method used in this research is cell number, and viability was measured with (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Treatments consisted of a combination of doxorubicin (0.02 μg/ml) and GpKar of 66.47 µg/ml (DES1), 132.94 µg/ml (DES2) and 265.89 μg/ml (DES3). The data were analyzed using a one-way ANOVA and Duncan post hoc tests. DES3 showed the lowest viability among treatments (89.32%). DES1 and DES2 showed high viability (>90%), 97.93%, and 95.08%, respectively. Thus, the combination of doxorubicin (0.02 μg/ml) and GpKar (66.47 µg/ml) was considered safe for further use in the following assay. In summary, the combination of doxorubicin and GpKar showed high viability in normal fibroblast cells.
Co-Authors Agung Novianto Betharie Cendera Arrahmani Hanna Sari Widya Kusuma Irfan Syarif Lilian Batubara Nunung Ainur Rahmah Said Nafik Susi Endrini Wahyu Widowati