<![CDATA[The research is motivated by whether the water fraction of beetroot can reduce total cholesterol levels in male white Swiss Webster mice. The aims are (1) to determine the effect of the water fraction of beetroot in reducing total cholesterol levels in male white Swiss Webster mice. (2) to find out the most optimum dose of the tuber water fraction variation lowers total cholesterol levels in male white Swiss webster mice compared to simvastatin. The method used in this research is experimental research using Swiss Webster male white mice as test animals. The beetroots used for the research were beetroots with the criteria of 2,900 grams of each tuber weighing 200-250 grams. completely randomized design (CRD) with 5 treatments and 5 replications. The data obtained were processed statistically using SPSS to determine the effect of the water fraction of beetroot on the decrease in total cholesterol levels which were analyzed using the ANOVA test. The results obtained in this study were (1) The water fraction of beetroot had activity in reducing total cholesterol levels in male white Swiss webster mice. (2) The results of a statistical test of the water fraction of beetroot showed that dose III (6.980 mg/20g BW) had the most optimum antilipemic activity compared to dose I (1.742 mg/20g BW) and dose II (3.484 mg/20g BW). Hasil dari uji statistik fraksi air umbi bit menunjukkan dosis III (6,980 mg/20g BB) memiliki aktivitas antilipemika paling optimum dibandingkan dengan dosis I (1,742 mg/20g BB) dan dosis II (3,484 mg/20g BB).]]>
