Hypertension is a disease that requires long-term therapy, so patient compliance is required in undergoing treatment to control blood pressure and reduce the risk of complications. Riskesdas data (2018) shows that the prevalence of non-compliance with taking medication in hypertensive patients is 32.3%. This study aims to determine the factors that influence compliance with medication use in hypertensive patients in primary health facilities. This research is a literature review research. Selection of research articles reviewed using the PRISMA method using relevant keywords (adherence to medication use, hypertension patients, primary level health facilities, influencing factors) and based on inclusion and exclusion criteria. The research was conducted at the STIKES Harapan Ibu Jambi Library from May to June 2023. Based on the research results, it is known that the factors that influence compliance with the use of antihypertensive drugs in hypertensive patients in primary-level health facilities are age, education, employment, knowledge, attitudes, motivation, family support, role of health workers, affordability of health services, duration of therapy and comorbid (p-value e<0.05). It is hoped that community health centers will provide education about the importance of compliance with the use of antihypertensive drugs in hypertension sufferers that is easy to understand so that they are compliant in taking antihypertensive medication.