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Relationship between Serum Homocysteine Levels and Manganese Superoxide Dismutase (MnSOD) on Retinal Nerve Fiber Layer (RNFL) Thickness in Diabetic Retinopathy and Non-Diabetic Retinopathy Patients: Oral Presentation - Observational Study - Resident Rini Nurrakhmah; Delfi; Rodiah Rahmawaty Lubis; Vanda Virgayanti
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/w9rgsd55

Introduction & ObjectivesDiabetic retinopathy is a visual disorder caused by abnormalities in the retina, where there is aprogressive microangiopathy characterized by damage and blockage of fine blood vessels, resultingin impaired nutrition of the retina. This study is to find out the relationship between serumhomocysteine levels and MnSOD on retinal nerve fiber layer (RNFL) thickness in diabeticretinopathy and non-diabetic retinopathy patients. MethodsThis study is an analytic observational case-control study with a total of 31 subjects for each group.3cc of venous blood samples were taken to assess the serum levels of homocysteine and MnSOD andthen analyzed by ELISA method in the integrated laboratory of the USU Medical Faculty. ResultsThere was a significant difference in Avg RNFL and Nasal RNFL thickness between the two groups(p=0.015) with the mean Avg RNFL thickness being 100.94 (SD=17.04) and the mean RNFL nasalthickness being 90.16 (SD=33.68). The highest MnSOD levels were found in non-diabeticretinopathy subjects with a mean of 142.77 (SD=101.77). There was no significant relationshipbetween homocysteine and thickness of superior RNFL (p=0.346), inferior RNFL (p=0.292),temporal RNFL (p=0.109), nasal RNFL (p=0.190). However, a significant association was foundbetween homocysteine and Avg RNFL (p=0.007). ConclusionIn the group of cases of diabetic retinopathy, a significant relationship was found between Hcy andAvg RNFL (p=0.007). An increase in serum homocysteine levels will be followed by a decrease in thethickness of the Avg RNFL.

THE EFFECT OF SERUM 25-HYDROXY VITAMIN D ON VISUAL FIELDS IN MODERATE - HIGH MYOPIA Ahmad Musa Simbolon; Bobby Ramses Erguna Sitepu; Rodiah Rahmawaty Lubis
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/frrdpf87

Introduction & ObjectivesMyopia is a visual impairment problem that constantly increases, causing global health problemsand economic burdens. Previous studies have concluded that vitamin D deficiency is associated withdecreased visual acuity and visual function. To determine the relationship between serum 25(OH)Dlevels and visual fields in moderate to high myopia MethodsThis study was an observational analytic study with a cross-sectional design. Visual function testsperformed were visual acuity test, Humphrey visual field analyzer, and ELISA test for serum25(OH)D. ResultsThe study consisted of 50 subjects with moderate to high myopia with 39 subjects was females (60%)and mean age of 26.62±3.70 years. The distribution of moderate myopia and high myopia was 30%and 20% with a mean spherical equivalent of -5.11±1.54 D. Twenty four subjects (48%) had serum25(OH)D deficiency, 1 subject (2%) had insufficiency of serum 25(OH)D with an average level of44.56±41.45 ng/ml. Fischer's Exact analysis on the right eye revealed 7 subjects (29.2%) had serum25(OH)D deficiency and insufficiency with visual field defect (p=0.001). On the left eye, 6 subjects(25%) had serum 25(OH)D deficiency and insufficiency with visual field defect (p=0.132). ConclusionThere was statistically significant relationship between serum 25(OH)D levels and visual field inmoderate to high myopia in one eye.

THE RELATIONSHIP OF INTERLEUKIN-6 LEVELS AND THE DEGREE OF MYOPIA IN YOUNG ADULTS IN NORTH SUMATRA UNIVERSITY HOSPITAL Salman Saisar Hidayat; Aryani Atiyatul Amra; Rodiah Rahmawaty Lubis
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/jqnkkw14

Background. Myopia is one of the refractive errors where parallel light from infinity is focused in front of the retina without accommodation. Various cytokines have been implicated in the development of myopia, including interleukin-6 (IL6) and matrix metalloproteinase-2 (MMP-2). IL-6 is one of the pro-inflammatory cytokines that play a role in ocular disease pathology. Chronic subclinical inflammation may play a role in elongation of the eyeball, inflammation promotes the breakdown of the scleral extracellular matrix and results in axial elongation. Objective. To determine the relationship of interleukin-6 levels and the degree of myopia in young adults in North Sumatra University Hospital. Methods. This research is an analytic observational study with a case control design, held from February 2022. Primary and secondary data are collected from interviews and direct observation. Bivariate analysis of differences in interleukin-6 levels in myopia and emmetropia uses T-independent test, if the data are normally distributed. If the data are not normally distributed, then the Mann Whitney test is used. Bivariate analysis to analyze differences in interleukin-6 levels based on the degree of myopia uses the Kruskal Wallis test, followed by a post hoc test using the Mann Whitney test and t-independent. Results. A total sample consists of 30 patients who suffer from myopia and 30 control samples. The mean age in the myopia group was 28.87 years with the youngest age being 25 years and oldest age 34 years. Most of them are moderate myopia with 15 people (50%). There was no significant difference in interleukin-6 levels between myopia and control groups (p = 0.147). There was a difference in the mean level of interleukin-6 based on the degree of myopia (p = 0.005). Conclusions. There is an association between interleukin-6 levels and the degree of myopia in young adult patients. No differences in interleukin-6 levels were found significant between myopia and control groups.

Challenging Management in Work-Related Eye Injuries: A Case Report of Steam Boiler Explosion-Induced Open Globe Injury: Poster Presentation - Case Report - Resident Rifhani Atthaya Putri; Rodiah Rahmawaty Lubis
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/n3szef56

Introduction : Work-related eye injuries (WREIs) are major health problems leading to vision loss worldwide. In this study, we reported a case of WREIs from blast injury caused by a steam boiler explosion Case Illustration : A 55-year-old male, laundry worker presented to the emergency unit with pain, bleeding, and sudden vision loss in the left eye, 8-hours after a blast injury from steam boiler. He was conscious with normal vital signs. He had lacerations to his left eyelid, frontal, and temporoparietal. Ocular examination revealed a visual acuity of no light perception, full-thickness laceration of the lower eyelid and inferior canalicular, diffuse subconjunctival hemorrhage, corneoscleral laceration with choroidal expulsion, and active bleeding. On investigation, B-scan ultrasonography revealed vitreous hemorrhage and CT scan showed no orbital fracture. He underwent evisceration, eyelid reconstruction, and lacrimal canaliculi repair surgery under general anesthesia and planned to custom-made ocular prosthesis. Discussion : WREIs include eyeball injuries, eye adnexa injuries, eyelid lacerations, and orbital wall fractures that occur during work-related activities. The incidence of WREIs is higher in men aged 20-40 years. In this case, the patient presented with an open globe injury resulting in sudden vision loss, requiring urgent surgical intervention to prevent further complications. Ocular prostheses can provide acceptable aesthetics and improve the patient's quality of life by helping them to integrate into society. Conclusion : WREIs can lead to permanent vision loss and require urgent surgical intervention. Employers must prioritize workplace safety by providing adequate training and appropriate eye protection such as safety goggles to minimize the risk of eye injuries.

COMPARISON OF CYSTATIN C LEVEL IN TEAR FLUID AND SERUM AS BIOMARKERS IN PRIMARY OCULAR TUMORS: Oral Presentation - Observational Study - Resident Ayu Aliyah; Rodiah Rahmawaty Lubis
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/xj9mck59

Abstract Introduction & Objectives : Cystatin C is known to play a role in tumor development and is expected to be used as a biomarker in eye tumors. This study aims to compare Cystatin C levels in tear fluid and serum as biomarkers in primary ocular tumors. Methods : This study is an analytical observational study with a case-control design. A total of 25 subjects with eye tumors in the study group and 25 subjects without eye tumors in the control group were included. Sampling was conducted from April 2022-July 2022 at the Eye Polyclinic of the Reconstructive Ocuplasty and Oncology division. The Mann-Whitney test was used with a significance level of 5%. Results : There was a significant difference in the tear fluid Cystatin C level between subjects with eye tumors and without eye tumors (p<0.001), with the mean tear fluid Cystatin C in the eye tumor group of 1.43 mg/dL. There was no significant difference in serum Cystatin C levels between groups of subjects with malignant eye tumors and benign eye tumors. However, there was a significant difference in the level of tear fluid Cystatin C between the groups of subjects with malignant eye tumors and benign eye tumors (p=0.042). Conclusion : In the case group, there was a significant relationship between tear fluid cystatin C levels and eye tumors (p < 0.001).

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