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All Journal Jurnal Ilmu Pertanian Indonesia
Indria Augustina
Department of Parasitology, Faculty of Medicine, Palangka Raya University, Jl. Yos Sudarso, Jekan Raya, Kota Palangka Raya, Kalimantan Tengah 74874
Agriculture, Biological Sciences & Forestry

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Journal : Jurnal Ilmu Pertanian Indonesia

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In Vitro Anthelmintic Activity of Orthosiphon aristatus (Blume) Miq Leaves Against Haemonchus contortus Indria Augustina; Debora Jesika; Pransiska Elma; Trinovita Elsa; Francisca Diana Alexandra; Arif Rahman Jabal
Jurnal Ilmu Pertanian Indonesia Vol. 29 No. 3 (2024): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.29.3.470

Abstract

Haemonchosis is an infection caused by the Haemonchus contortus worm, a blood-sucking gastrointestinal parasite that can also infect humans. Orthosiphon aristatus (Blume) Miq leaves have been shown to have anthelmintic activity due to the presence of saponins, flavonoids, and tannins. This study aimed to determine the anthelmintic activity of ethanol extract of Orthosiphon aristatus (Blume) Miq leaves against H. contortus. The infective H. contortus larvae were divided into six treatment groups: a 0.5% ethanol extract concentration group, a 1% ethanol extract concentration group, a 2% ethanol extract concentration group, a 4% ethanol extract concentration group, a positive control group (+), and a negative control group (-), each with four replicates. The study was conducted in six hours, with observations made at the 1st, 2nd, 4th, and 6th hours. The results showed that the death of the larvae increased with higher ethanol extract concentrations and longer exposure to the ethanol extract of Orthosiphon aristatus (Blume) Miq leaves. The time of death for infective H. contortus larvae given the ethanol extract of Orthosiphon aristatus (Blume) Miq leaves was at the 4th hour, and the effective dose of the ethanol extract as an anthelmintic was at the concentration of 0.5%. Keywords: Anthelmintic, Haemonchus contortus, Orthosiphon aristatus
Co-Authors Arif Rahman Jabal Debora Jesika Elsa Trinovita Francisca Diana Alexandra Pransiska Elma