<![CDATA[Background: Acne or acne vulgaris an inflammatory disorder derived from the follicle pilosebasea. The trigger bacteria is Propionibacterium acne., which often appears in adolescence. This condition is a very common skin disorder present with inflammatory and non-inflammatory lesions especially in the face, but it can happen in other parts of the body like the upper arm and the back. Purified ethanol extracts of betel green betel leaf concentration 20mg / ml has very strong antibacterial activity against Propiobacterium acne. Another study on the red betel leaf proved to have a Propionibacterium acne activity of concentration 10 %, 15 %, 20 % and 25 %. The next betel variety is that the black betel leaf has its benefits as the Propionibacterium acne antibacterium concentration 5 %, and strong activity zones at 10 % concentrations. Method: This research is experimental. Samples from this study are betel leaf green, Red betel and black betel. Samples of a fresh, domesticated plant, And then dried up in the wind. Next, there's an extraction of three-by-four-hour masseration methods with an hour-to-hour solvent change for each variety of betel leaf. The extraction results are applied to the solvent until it becomes a thick extract. Phytochemical screening is done to ensure any group of compounds extracted .Antibacterial testing using diffusion disk methods with concentration 5 %, 10 % and 15 % for each extract and extract combination with comparison (1: 1 ). Result: Screening results show an extract of ethanol 96 % green betel leaves (Piper betle L) and red betel (Piper crocatum ) positive alkaloid secondary metabolic compound, terpenoid, steroids, tannin, and flavonoids. Extract black betel leaf (Piper betle L. Var nigra ) positive is an alkaloid positive, terpenoid, steroids, tannin, saponin and flavonoid compound. Antibacterium Propionibacterium acne test results show the average positive control zone disk antibiotics clindamisin 8.67 mm strong categories, while for extracting concentration 15 % betel green is 8.69 mm strong category, Red betel 2.71 mm weak category, black betel 1.8 mm weak category, 577 mm medium red-green betel combination, 477 mm black-green betel. medium category and red-black betel of 1.89 weak categories. Normality test with result p>0,05 and the non parametric test of krkskall-wallis results asym sip values are 0,0000 (p<0,05) there is a significant difference between two group samples. Conclusion: The largest average value of the clear zone occurs on a concentration of 15 % green betel extract with 8.69 mm.]]>
