The research aims to: (1) determine the need for the development of a learning management information system in information technology-based entrepreneurship courses in supporting the Merdeka Belajar Kampus Merdeka (MBKM) program in Higher Education; ((2) To develop; (2) Develop a model of learning management information system in information technology-based entrepreneurship courses in supporting MBKM that is valid and effective in use. The study used a 4D model development design consisting of 4 stages of development, starting from the design stage, the develop and disseminate stages, with an analysis of the validity of the instrument using the Aiken'v formula, reliability analysis with Cronbach's alpha, and the practicality of the learning management information system using a Likert scale, involving 25 students at Akba Makassar University of Technology. The results showed that the Learning Information System using the learning management system (LMS) in entrepreneurship courses at Akba Makassar University of Technology was very practical, as evidenced by the positive responses from both students and lecturers and the results of the effectiveness test of using the system showed very effective. This shows that the LMS effectively supports IT-based entrepreneurship learning, improves the overall educational experience for students and facilitates more efficient teaching practices for lecturers. then the results of data analysis show that the learning management information system for information technology-based entrepreneurship courses in supporting the MBKM program is practical and feasible to use.