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All Journal Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima
Lister, Clarissa
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Inhibitory ability of robusta coffee bean extract against Staphylococcus epidermidis Lister, Clarissa; Ginting, Rapael; Panggabean, Endah Ansylla; Tarigan, Ermilia Laurensya
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5710

Abstract

Background: Treatment of infections generally uses chemical antibiotics, but chemical antibiotics have effects such as increasing toxicity to the body. The solution to overcome this problem is to use antibiotics from natural ingredients, such as coffee. Objective: This study aims to determine the effectiveness of robusta coffee bean extract (Coffea canephora) in inhibit the growth of Staphylococcus epidermidis bacteria. Methods: This research is an experimental study with a post test only control group design. There were 10 groups in this study, namely 2 control groups and 8 treatment groups. The technique used is disc diffusion to see the role of robusta coffee bean ethanol extract in inhibiting the growth of Staphylococcus epidermidis bacteria. The data was analyzed using the Mann-Whitney test to determine the difference between treatments. Results: The results of the Mann-Whitney test showed that there were differences in the average inhibition zone of Robusta coffee bean extract and the inhibitory power at each concentration (p<0.05). The concentration that has the highest inhibition is the concentration of 500 mg/ml. Conclusion: It can be said that there is an effectiveness of robusta coffee bean extract in reducing Staphylococcus epidermidis bacteria because the specified concentration inhibition zone is obtained.
The effect of telang flower extract on kidney function and histopathological features of obese rat kidneys Astuti, Mia Puji; Lister, Clarissa; Renaldi, Muhammad Rizal; Suhartina, Suhartina
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.5453

Abstract

This study aims to determine the effect of oral administration of telang flower extract in several doses on histopathological changes in kidney organs. This study used a post test only control group design. Researchers used 6 Wistar rats for each experimental group, so that the total number of test animals in this study was 24. Grouping of test animals was done randomly into 4 test groups. Histopathological observations of kidney tissue were made by comparing the control and treatment groups. Changes observed will be the presence of fatty degeneration (vacuolization), necrosis and hydrophic degeneration. To obtain quantitative data, scoring was performed on each change found. The data from the study were then analyzed with the help of SPSS. Data normality test was analyzed by Kolmogorov-Smirnov test (p > 0.05). To test the significance between test groups, one-way analysis of variance or One Way ANOVA technique was conducted at 95% confidence level (p < 0.05). Further analysis or test was conducted using Post Hoc Test with LSD technique. The results showed that the administration of telang flower extract at a dose of 600mg/KgBB was effective in improving kidney function in obese Wistar white rats. This improvement is seen through increased levels of ureum, creatinine, and improved renal histological structure. Histopathological observation of kidney tissue showed that treatment group 3, which received telang flower extract at a dose of 600mg/KgBB, experienced significant improvement and was closer to the control group than the other groups.
Co-Authors Astuti, Mia Puji Ginting, Rapael Panggabean, Endah Ansylla Renaldi, Muhammad Rizal Suhartina Suhartina, Suhartina Tarigan, Ermilia Laurensya