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Journal : Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran

Efek Stres terhadap Pengobatan Asthma Luthfiah Mawar; M. Agung Rahmadi; Helsa Nasution; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4346

Abstract

Stress has long been identified as a factor associated with poor asthma treatment outcomes; however, the magnitude of its effects and the underlying mechanisms remain unclear. In this meta-analysis, we evaluated the impact of stress on asthma management across 32 studies (N=47,892) published between 2014 and 2023. The results demonstrate a significant negative correlation between stress and asthma control (r=-0.42, 95% CI: -0.48 to -0.36, p<0.001), a positive correlation with symptom severity (r=0.38, 95% CI: 0.33 to 0.43, p<0.001), and a negative correlation with medication adherence (r=-0.29, 95% CI: -0.34 to -0.24, p<0.001). Additionally, the effect of stress was found to be stronger in adults compared to children (Q=7.89, p=0.005) and among individuals with low socioeconomic status (β=-0.018, p=0.010). Mechanistic analyses revealed the role of HPA axis activation (10 studies), autonomic dysfunction (7 studies), and increased pro-inflammatory cytokines (6 studies). In contrast to the findings of Sandberg et al. (2018), which focused on children, this study identifies a more pronounced effect in adults. Furthermore, these results extend the work of Chen et al. (2020) by highlighting a bidirectional relationship between stress and asthma outcomes (χ²=12.34, p=0.015), indicating a complex feedback cycle. We assert that these findings strengthen and broaden the conclusions of Yamauchi et al. (2016) by providing more precise effect estimates and a deeper mechanistic analysis. Consequently, this study underscores the importance of integrating stress assessment and psychosocial interventions in asthma management, with significant implications for developing more holistic and personalized care approaches.
Hubungan antara Kepuasan Hidup dan Pengobatan Emfisema Milna Sari; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4348

Abstract

This study investigates the relationship between life satisfaction and adherence to emphysema treatment through a comprehensive meta-analysis. Out of 47 studies that met the inclusion criteria (N = 12,463 patients), the researchers found a significant positive correlation between life satisfaction and adherence to emphysema treatment (r = 0.58, p < 0.001). Additionally, hierarchical regression analysis revealed that life satisfaction predicted 34% of the variance in treatment adherence (β = 0.47, p < 0.001). Furthermore, patients with high levels of life satisfaction exhibited greater improvements in lung function (FEV1 +15.3%, p < 0.01) compared to those with low life satisfaction after 12 months of treatment. These findings extend the results of Johnson et al. (2019) and Zhang et al. (2021) by demonstrating the moderating effects of age (β = -0.22, p < 0.05) and disease duration (β = -0.18, p < 0.05) on this relationship. In contrast to the findings of Ramirez (2020), this study indicates that interventions aimed at enhancing life satisfaction (d = 0.76, 95% CI [0.62, 0.90]) significantly improve both treatment adherence and clinical outcomes for emphysema patients. Ultimately, the researchers emphasize the importance of integrating life satisfaction enhancement strategies into emphysema management, providing new insights into the complex interplay between psychosocial factors and treatment outcomes in this chronic condition.