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All Journal Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Romaito Nasution
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Dentistry Health Professions Nursing Public Health Veterinary

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Hubungan antara Perasaan Bersalah dan Keberhasilan Pengobatan Lupus Romaito Nasution; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Milna Sari
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1858

Abstract

This study analyzes the relationship between guilt and treatment outcomes in lupus patients through a meta-analysis of 15 studies (N = 2,876). The results indicate a significant negative correlation (r = -0.32, 95% CI [-0.39, -0.25], p < 0.001) between levels of guilt and lupus treatment success. Moderator analysis revealed a stronger relationship in younger patients (β = 0.015, SE = 0.006, p = 0.013) and those with a shorter disease duration (β = -0.021, SE = 0.009, p = 0.019). The strongest correlation was found in the disease activity dimension (r = -0.38, 95% CI [-0.46, -0.29]) compared to quality of life (r = -0.30, 95% CI [-0.38, -0.21]) or medication adherence (r = -0.25, 95% CI [-0.34, -0.15]). Furthermore, mediation analysis revealed that coping strategies mediated 34% of the effect of guilt on treatment outcomes. Longitudinal findings confirmed that a decrease in guilt is associated with improved treatment outcomes (r = -0.29, 95% CI [-0.41, -0.16], p < 0.001). These findings extend Witvliet et al. (2001) regarding the impact of guilt on health and support Engel's biopsychosocial model (1977) in the context of lupus. Unlike Navarrete-Navarrete et al. (2010), which focused on a single case, this research provides large-scale quantitative evidence. Finally, the primary novelty of this study lies in identifying the non-linear relationship between guilt levels and treatment outcomes, as well as the moderating role in psychological interventions (Q = 4.12, df = 1, p = 0.042). Thus, the findings underscore the importance of integrating guilt assessment and management in lupus care, supporting a holistic approach that combines psychological interventions with medical treatment.
Peran Harapan dalam Kepatuhan Pengobatan Kanker Kolorektal M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawa; Romaito Nasution; Milna Sari
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 6 (2024): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i6.793

Abstract

This meta-analysis investigates the relationship between hope and medication adherence in colorectal cancer (CRC) patients. Out of 1,247 identified articles, 18 studies met the inclusion criteria, encompassing 3,562 patients. The findings reveal a significant positive correlation between hope and medication adherence (r = 0.42, 95% CI: 0.35-0.49, p < 0.001), with notable heterogeneity (I² = 76.4%, Q = 72.03, df = 17, p < 0.001). Furthermore, subgroup analyses indicate a stronger effect in patients with advanced-stage cancer (r = 0.49, 95% CI: 0.39-0.58) compared to those in various earlier stages (r = 0.38, 95% CI: 0.30-0.46, Q = 4.12, df = 1, p = 0.04). No significant differences were found regarding the influence of hope on medication adherence based on treatment type or the country of the study. Additionally, this research extends the findings of DiMatteo et al. (2000) concerning the impact of depression on medication nonadherence, emphasizing the importance of positive psychological states. Moreover, the larger effect size observed for self-efficacy and adherence (r = 0.31) reported by Hall et al. (2016) underscores the relative significance of hope in CRC medication adherence. The novelty of this research lies in its comprehensive synthesis of the hope-adherence relationship within the CRC context, clarifying the varied and partial findings of Zhu et al. (2017) and García-Torres et al. (2016). Consequently, these results support the development of hope-based interventions to enhance medication adherence, as Snyder (2002) suggested in the specific context of CRC. Future research should focus on longitudinal analyses and intervention trials to clarify causal relationships and the effectiveness of hope-based approaches in improving CRC medication adherence.
Efek Stres terhadap Pengobatan Asthma Luthfiah Mawar; M. Agung Rahmadi; Helsa Nasution; Ika Sandra Dewi; Romaito Nasution; Milna Sari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4346

Abstract

Stress has long been identified as a factor associated with poor asthma treatment outcomes; however, the magnitude of its effects and the underlying mechanisms remain unclear. In this meta-analysis, we evaluated the impact of stress on asthma management across 32 studies (N=47,892) published between 2014 and 2023. The results demonstrate a significant negative correlation between stress and asthma control (r=-0.42, 95% CI: -0.48 to -0.36, p<0.001), a positive correlation with symptom severity (r=0.38, 95% CI: 0.33 to 0.43, p<0.001), and a negative correlation with medication adherence (r=-0.29, 95% CI: -0.34 to -0.24, p<0.001). Additionally, the effect of stress was found to be stronger in adults compared to children (Q=7.89, p=0.005) and among individuals with low socioeconomic status (β=-0.018, p=0.010). Mechanistic analyses revealed the role of HPA axis activation (10 studies), autonomic dysfunction (7 studies), and increased pro-inflammatory cytokines (6 studies). In contrast to the findings of Sandberg et al. (2018), which focused on children, this study identifies a more pronounced effect in adults. Furthermore, these results extend the work of Chen et al. (2020) by highlighting a bidirectional relationship between stress and asthma outcomes (χ²=12.34, p=0.015), indicating a complex feedback cycle. We assert that these findings strengthen and broaden the conclusions of Yamauchi et al. (2016) by providing more precise effect estimates and a deeper mechanistic analysis. Consequently, this study underscores the importance of integrating stress assessment and psychosocial interventions in asthma management, with significant implications for developing more holistic and personalized care approaches.
Hubungan antara Kepuasan Hidup dan Pengobatan Emfisema Milna Sari; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Ika Sandra Dewi; Romaito Nasution
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4348

Abstract

This study investigates the relationship between life satisfaction and adherence to emphysema treatment through a comprehensive meta-analysis. Out of 47 studies that met the inclusion criteria (N = 12,463 patients), the researchers found a significant positive correlation between life satisfaction and adherence to emphysema treatment (r = 0.58, p < 0.001). Additionally, hierarchical regression analysis revealed that life satisfaction predicted 34% of the variance in treatment adherence (β = 0.47, p < 0.001). Furthermore, patients with high levels of life satisfaction exhibited greater improvements in lung function (FEV1 +15.3%, p < 0.01) compared to those with low life satisfaction after 12 months of treatment. These findings extend the results of Johnson et al. (2019) and Zhang et al. (2021) by demonstrating the moderating effects of age (β = -0.22, p < 0.05) and disease duration (β = -0.18, p < 0.05) on this relationship. In contrast to the findings of Ramirez (2020), this study indicates that interventions aimed at enhancing life satisfaction (d = 0.76, 95% CI [0.62, 0.90]) significantly improve both treatment adherence and clinical outcomes for emphysema patients. Ultimately, the researchers emphasize the importance of integrating life satisfaction enhancement strategies into emphysema management, providing new insights into the complex interplay between psychosocial factors and treatment outcomes in this chronic condition.
Co-Authors Helsa Nasution Ika Sandra Dewi Luthfiah Mawa Luthfiah Mawar M. Agung Rahmadi Milna Sari