Garuda - Garba Rujukan Digital

Lely Adel Violin Kapitan

Poltekkes Kemenkes Kupang

Author-ID : 817623

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Neuroscience Nursing Public Health Other

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Aktivitas Antimikroba Ekstrak Laos Putih (Alpinia Galangas) Terhadap Bakteri Escericia Coli Dan Salmonella Sp. Kapitan, Lely Adel Violin
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Poltekkes Kemenkes Kupang

Telah dilakukan penelitian tentanguji aktivitas antibakteri ekstrak etanol Laos putih (Alpinia galanga S) terhadap pertumbuhan bakteriEscericia coli dan bakteri Salmonella sp. Ekstrak etanol Laos putih yang digunakan adalah ekstrak etanol Laos putih yang diperoleh melalui ekstraksi dengan pelarut etanol 70% menggunakan metode perkolasi. Efektivitas ekstrak etanol laos putih diuji dengan metode difusi menggunakan silinder. Aktivitas antibakteri dari ekstrak etanol Laos putih diketahui dengan melihat adanya zona hambat yang berupa daerah bening di sekitar silinder, kemudian diukur menggunakan jangka sorong. Percobaan menggunakan Rancangan Acak Lengkap dengan 5 perlakuan dan 3 kali ulangan . Data yang diperoleh kemudian dianalisis secara statistik menggunakan analisis sidik ragam (ANOVA). Hasil penelitian memperlihatkan bahwa nilai F Tabel 1 % < F Hitung. Uji selanjutnya menggunakan Uji Beda Nyata Jujur (BNJ) memperlihatkan koefisien keragaman 0,51 % < 5 % menunjukkan ada perbedaan yang nyata dari tiap perlakuan yang diujikan. Dari hasil tersebut maka dapat disimpulkan bahwa ekstrak etanol Laos putih memiliki aktivitas antibakteri terhadap pertumbuhan bakteri Escericia coli mulai konsentrasi 25 % dengan luas zona hambat 10,45 mm2 dan bakteri Salmonella sp mulai konsentrasi 25 % dengan luas zona hambat 17,45 mm2. Semakin tinggi konsentrasi semakin luas Zona hambatan.

Aktivitas Antimikroba Ekstrak Laos Putih (Alpinia Galangas) Terhadap Bakteri Escericia Coli Dan Salmonella Sp. Lely Adel Violin Kapitan
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

A study was conducted on antibacterial activity of white Laos ethanol extract (Alpinia galanga S) on the growth of Escherichia coli bacteria and Salmonella sp bacteria. The white Laos ethanol extract used was a white Laos ethanol extract obtained by extraction with 70% ethanol solvent using percolation method. The effectiveness of white laos ethanol extract was tested by a diffusion method using cylinder. The antibacterial activity of the white Laos ethanol extract is known by observing a drag zone in the clear region around the cylinder, then measured using a sliding range. The experiment used Completely Randomized Design with 5 treatments and 3 replications. The data obtained were then analyzed statistically using analysis of variance (ANOVA). The results showed that the value of F Table 1% <F Count. Subsequent tests using the Honest Real Difference Test (BNJ) showed a diversity coefficient of 0.51% <5% indicating there was a marked difference between each treatment being tested. From these results, it can be concluded that the extract of white Laos ethanol has antibacterial activity against the growth of Escherichia coli bacteria starting at 25% concentration with 10.45 mm2 inhibitory zone and Salmonella sp bacteria starting at 25% concentration with 17,45 mm2 inhibit zone. The higher the concentration the wider the barrier zone.

Total flavonoid content and analgesic activity of ethyl acetate fraction of Indian jujube (Ziziphus mauritiana lamk) leaves Priska Ernestina Tenda; Fatmawati Blegur; Lely A.V Kapitan
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Indian jujube leaves (Ziziphus mauritiana Lamk) have various potential biological activity. Previous studies have proven that ethanol extracted from Indian jujube (Z. mauritiana Lamk) leaves had analgesic activity. This study aimed to determine the total flavonoid content and analgesic activity of the ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves ethanol extract. Tested fraction was prepared by maceration using ethanol as solvent followed by fractionation using ethyl acetate. Identification of active compounds was performed using color reaction, and determination of total flavonoids by colorimetric method. Ethyl acetate fraction was further tested for its analgesic activity using the writhing method. Swiss-Webster white male mice were divided into 5 treatment groups consisting of negative control contained sodium-CMC, positive control contained sodium diclofenac, while groups 3-5 were given ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves with doses of 50, 150, and 200 mg/kg BW. All interventions were administered as a single oral dose. 0.7% (w/v) acetic acid was used as a pain inducer. Analgesic activity was measured by calculating the percentage of writhing protection as a measure of the analgesic effect produced by each intervention. The data were analyzed using one-way Anova to compare analgesic activity between treatment groups. Results showed that ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves at doses of 50, 150, and 200 mg/kg BW gave an effect that was not significantly different from sodium diclofenac as positive control. The ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves ethanol extract contained flavonoids, saponin, and tannins with total flavonoid content of 22.41 ± 1.16% w/w. It can be concluded that the ethyl acetate fraction of Indian jujube (Z. mauritiana Lamk) leaves have analgesic activity in mice.

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