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All Journal Microbiology Indonesia Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Pharmasipha Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Kefarmasian Indonesia
Erika Indah Safitri
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Pharmaciana: Jurnal Kefarmasian

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Chemical qualitative analysis and spf value stability of nutmeg seed oil in microemulsions with tween 80 and PEG 400 as surfactants and cosurfactants Ayu Shabrina; Erika Indah Safitri; Risha Fillah Fithria; Misbahul Munir; Sumantri Sumantri
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1034.753 KB) | DOI: 10.12928/pharmaciana.v12i1.21997

Abstract

Nutmeg oil contains α-pinene, which can be used as sunscreen. The combination of Tween 80 and PEG 400 can maintain the stability of nutmeg oil microemulsion. This research was a follow-up study that aims to determine the stability of the SPF value and qualitative chemical content of nutmeg seed oil microemulsions (NSM). NSM was made with a nutmeg seed oil concentration of 6.4% and tween 80 and PEG 400 as surfactants and cosurfactants with variations in the ratio of F1 (5: 4), F2 (6: 4), and F3 (7: 4). Nutmeg seed oil and NSM content was analyzed using GC-MS. NSM formula were tested for in vitro SPF value stability by storing NSM in a climatic chamber at 30 °C ± 2 °C with RH 65 % ± 5 % for 4 weeks. The SPF values were calculated every week. GC-MS data were analyzed descriptively and data of SPF value stability were analyzed statistically using one way ANOVA. The GC-MS results of nutmeg seed oil showed 35 components, including significant compounds, namely α-pinene, sabinene, β-phellandrene and also α-terpinolene. GC-MS results of NSM showed those significant compounds were still detected after being formulated in microemulsion. The results of the sunscreen activity test of NSM before storage were 10.31 ± 0.03 (F1); 10.47 ± 0.07 (F2); 10.45 ± 0.03 (F3) and did not show significant change after storage for 4 weeks (p > 0.05). The SPF values of NSM were categorized in maximum activity. 
Co-Authors Asri Melati Dewi AULIA EVERESTINA PUJAKA Ayu Shabrina Danang Yogo Wijaya Devi Nisa Hidayati Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dewi Listianingsih Dwi Ayu Mustikaningsih Dwi Lutvi Alviani Dwi Nadya Jayanthy Eko Wahyu Saputro Fera Elia Fita Ibrahim Arifin Intan Pratiwi Jeni Anggraini Laili Nailul Muna Masita Nur Amalia Putri Maulita Cut Nuria Misbahul Munir Raka Galih Pradana risha fillah fithria Risha Fillah Fitria Siska Maila Sari Sumantri Sumantri Syahrul Iqbal Setiawan Yance Anas Yunita Ayu Hapsari