Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal MNJ (Malang Neurology Journal)
Ulhaq, Zulvikar Syambani
Malang Neurology Journal
Neuroscience

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
AROMATASE AND NEUROREGENERATION Ulhaq, Zulvikar Syambani
Malang Neurology Journal Vol 5, No 1 (2019): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.01.9

Abstract

Aromatase (cyp19a1) is a converting enzyme for estrogen biosynthesis. A single gene of cyp19a1 identified in mammals and specific promoter differentially regulates E2 produce in the brain.Interestingly, teleost fish having two isoforms of cyp19a1, cyp19a1a and cy19a1b, encoding ovarian and brain aromatase, respectively. In addition, teleost fish are characterized by having highly aromatase activity and neuroregenerative response. In contrast with fish, neuroregeneration process is limited in mammals. Therefore, understanding molecular mechanism of estradiol signaling in neural injury in fish may give a new insight for the development of novel treatment in mammals, particularly in neurodegenerative diseases. Here, the author briefly reviews and discusses the potential role of neural estrogen for regeneration process.
Co-Authors