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Annisa, Rahmi
Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULATION AND CHARACTERIZATION OF SUNSCREEN MICROEMULSION OF PINEAPPLE EXTRACT (Ananas comosus (L.)) WITH SYNERGISTIC EFFICACY ON SUN PROTECTION FACTOR (SPF) Mutiah, Roihatul; Sukma, Yolanda Cahyaning; Megawati, Dewi Sinta; Annisa, Rahmi
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.7727

Abstract

The root of Calotropis gigantea (thistle) is an Indonesian herb to treat cancer based on empirical and scientific evidences. The study aims to find out the infuence of ethanol extract of Calotropis gigantea root in inhibiting cancer cell growth of Mus musculus fibrosarcoma in vivo and to find out metabolite compound in the Calotropis gigantea root extract. The effect of cancer cell growth inhibition was tested on Mus musculus inducted with 7.12-dimetilbenz (α) antrasena (DMBA) and dose treatment of 50, 100 and 150 mg/Kg body weight. The metabolomic analysis on the root employs UPLC-QToF-MS/MS as a positive ESI ion source, the movement phase of water/acid mixture is 99.9/0.1 [v/v] and acetonitrile/formic acid was 99.9/0.1 [v/v] with gradient elution system and stationary phase of C18. The chromatogram was analyzed using Masslynx 4.1. The component identification was based on the m/z ratio measured in Masslynx and m/z counted in chemdraw. The result of the study showed that the Calotropis gigantea root extract with the dose of 50, 100 dan 150 mg/Kg body weight were able to increase the weight of fibrosarcoma mice and have a significant influence on caspase-3 expression with cell apoptosis index 24.3 %; 13.3 % and 12.3 % respectively. The result of metabolomic analysis showed 14 compounds found in the root extract. There are two major compounds: 4-Chlorobenzenethiol with the area 32.51% and N-[1-(Adamantan-1-yl) ethyl]-2-(1-piperidinyl)-4-quinazolinamine with the area 37.20%. They are indicated responsible for the anticancer activity of Calotropis gigantea root extract. Keywords: Calotropis gigantea, caspase-3, fibrosarcoma, metabolomic, UPLC-QToF-MS/MS
ANTICANCER ACTIVITIES AND METABOLITE FINGERPRINTING OF UPLC-QToF-MS/MS METHOD FROM Chrysanthemum cinerariifolium (Trev) Listiyana, Anik; Lestari, Nia Ayu; Irawati, Santia; Indrawijaya, Yen Yen Ari; Annisa, Rahmi; Bhagawan, Weka Sidha; Mutiah, Roihatul; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.7728

Abstract

Chrysanthemum cinerariifolium (C. cinerariifolium) is an empirically proven medicinal plant that has anticancer activities. This study aimed to profile metabolites, and cytotoxic activity of root, leaf, stem, and root extracts C. cinerariifolium on T47D cells and to determine the correlation of metabolite content with cytotoxic activity. The metabolite profile was carried out using UPLC-QToF-MS / MS, and cytotoxic activity was carried out using the MTT method. The results obtained in the form of a chromatogram were processed with the application Masslynk so that a metabolite profile data obtained. The data is then analyzed statistically using Principal Component Analysis (PCA). The results obtained on metabolite profiling showed that there were differences in metabolite profiles in the roots, stems, leaves, and chrysanthemums. The characteristic compounds in the flower section are D - (-) - Morphine and in the leaf part of genistein  and N - [(5-Chloro-1,2,3-thiadiazol-4-yl) methyl] -1- (2-isopropyl-4 -methyl-1,3-thiazol-5-yl) -N-methyl ethanolamine. The major compounds in the roots, stems, and leaves are Orphenadrine with successive percentages of 9.11%, 10.16%, and 3.24%, and the major compounds in the flower section are D - (-) - Morphine with a percentage of 10, 86%. Furthermore, the results of the cytotoxic activity test showed differences in anticancer cytotoxic activity in the parts of the flower, leaf, stem, and root of C. cinerariifolium. Besides, there is a relationship between the metabolite content and anticancer cytotoxic activity of each part of C. cinerariifolium. The higher the level of orphenadrine compounds in the plant, the higher the potential for anticancer. Keywords: C. cinerariifolium, UPLC-QToF-MS/MS, T47D cells.
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF Staphylococcus aureus MICROEMULSION OF ANTING-ANTING (Acalypha indica) LEAF EXTRACT USING ISOPROPYL MIRISTAT AS OIL PHASE Husniyah, Jauharatul; Annisa, Rahmi; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4991

Abstract

Leaf of Anting-Anting (Acalypha indica) is one of the plants that contain potent flavonoid compounds as antibacterial Staphylococcus aureus. The purpose of this research is to know physical characteristic of microemulsion of A. Indica leaf extract and to know antibacterial activity against Staphylococcus aureus bacteria. The microemulsions in this study used isopropyl myristate as the oil phase, tween 80 and span 80 as surfactant, isopropanol as kosurfactant and free water from CO2. Microemulsion was made by varying the concentration of the extract into 3 formulas, there are 5%, 10% and 15%. A. indica extract obtained using ultrasonic maseration extraction method with 70% ethanol solvent. All the formulas were evaluated for the characteristics of the preparations and the antibacterial activity test against Staphylococcus aureus bacteria with the sumuran diffusion method. The research results showed that the microemulsion of A. indica leaf extract has good physical characteristic with pH value between 4.9-5.8, deep oil type, that particle size F1 9.34 μm, F2 14.22 μm and F3 9.68 μm and stable physically at 25°± 2°C and 40°± 2°C. The result of antibacterial activity test showed that F1 did not differ significantly with positive control. However, the inhibitory power of F1 is still under positive clindamycin control of 12.98 mm and 15.05 mm. So it can be collected that F1 is an ideal formula which has good physical characteristics and has optimum drag power.
Co-Authors Anik Listiyana Bhagawan, Weka Sidha Dewi Sinta Megawati, Dewi Sinta Husniyah, Jauharatul Indrawijaya, Yen Yen Ari Irawati, Santia Lestari, Nia Ayu Ma'arif, Burhan Mutiah, Roihatul Sukma, Yolanda Cahyaning