Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline
Febriyanti, Maya
Universitas Pakuan
Chemistry Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
SITOTOKSISITAS KOMBINASI EKSTRAK PUSPA (Schiima wallichii) DANKECAMBAH BROKOLI iv (Brassica olerasea) TERHADAP SEL KANKER PAYUDARA MCF-7 Diantini, Ajeng; Febriyanti, Maya; Intan Barliana, Melisa; Abdulah, Rizky
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 3, No 1 (2013): FITOFARMAKA
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.433 KB)

Abstract

Puspa (Schiima wallichii) diketahui memiliki aktivitas antikanker melalui mekanisme menginduksi apoptosis pada sel kanker payudara MCF-7, sedangkan kecambah brokoli (Brassica olerasea) dilaporkan dapat menghambat proliferasi sel-sel kanker kandung kemih dan prostat secara in vitro. Pada penelitian ini dilakukan pengujian sitotoksisitas kombinasi ekstrak puspa (EP) dan ekstrak kecambah brokoli (EKB) terhadap sel kanker payudara MCF-7. EP memberikan nilai IC 50 60,76 µg/ml, sedangkan EKB tidak memberikan persentasi inhibisi lebih besar dari 50% pada rentang konsentrasi uji. Sitotoksisitas kombinasi EP-EKB dengan perbandingan IC 50 1:2 memiliki nilai Indeks Kombinasi < 0,9 menunjukkan bahwa kombinasi EP-EKB memberikan efek sinergisme. Kata kunci :puspa, kecambah brokoli, sinergisme, MCF-7
Kandungan Kimia dan Aktivitas Sitotoksik Ekstrak dan Fraksi Herba Anting-anting terhadap Sel Kanker Payudara MCF-7 Febriyanti, Maya; Supriyatna, .; Abdulah, Rizky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.469 KB)

Abstract

Acalupha indica, belongs to Euphorbiaceae family, is annual herb which distributed widely in Asia, including Indonesia. Extract and fraction of Acalypha indica were sreened for phytochemical constituents and investigated for its cytotoxicity against human breast cancer MCF-7 using MTT assay. Ethanolic extract of A.indica showed cytotoxicity against MCF-7 with an IC50 225 μg/ml. While for the fraction, ethyl acetate fraction showed best cytotoxicity compared to n-hexane and water fraction with an IC50 387 μg/ml. Phytochemical screening to the ethyl acetate fraction showed that the fraction contain flavonoids, polyphenols, monoterpenes and sesquiterpenes, triterpenoids, and quinones.Keywords : Acalypha indica, cytotoxicity, MCF-7, MTT assay
Co-Authors . Supriyatna, . Ajeng Diantini, Ajeng Intan Barliana, Melisa Rizky Abdulah