Majalah Kedokteran Neurosains
Vol 30 No. 2 Maret 2013

EKSPRESI KASPASE 8 DAN PERUBAHAN JUMLAH SEL NEUROGLIA PADA REGULASI MEKANISME APOPTOSISSEL OTAK AKIBAT KERACUNAN MERKURI

Paulus Sugianto, Abdulloh Machin, Hanik Badriyah Hidayati, Moh. Hasan Machfoed (Unknown)

Article Info

Publish Date
05 Mar 2020

Abstract

INTRODUCTION MERCURY IS A POTENT NEUROTOXIN SINCE IT INDUCES APOPTOSIS AND INFLAMMATORY RESPOND IN BRAIN CASPASES EG CASPASE 8IS ONE OF CENTRAL EFFECTORS OF APOPTOSIS AND SERVE AS SIGNALING MEDIATORS THAT ORCHESTRATE APOPTOTIC EXECUTION PATHWAYS BY CLEAVING A SUBSET OF CELLULAR PROTEINS WHEREAS BRAIN INFLAMMATORY RESPONSE IS TRIGGERED BY THE ACTIVATION OF NEUROGLIAL EG MICROGLIAL CELLS AND ASTROCYTES AND THIS GLIAL REACTIVITY HAS BEEN USED AS AN EARLY MARKER OF NEUROTOXICITYTO STUDY THE EFFECTS OF NEUROTOXICITY MERCURY WE USE CASPASE 8 AND MICROGLIAL AS A PARAMETER OF METHYL MERCURY NEUROTOXICITY

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Journal Info
Majalah Kedokteran Neurosains
Website

Abbrev

NEURONA

Publisher

The Indonesian Neurological Association

Subject

Neuroscience

Description

Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains di Indonesia. Jurnal ini diterbitkan setiap 3 bulan sekali oleh Perhimpunan Dokter Spesialis Saraf di Indonesia. Pastikan Anda telah terdaftar menjadi pelanggan untuk dapat mengunduh artikel ...