Hanik Badriyah Hidayati, Hanik Badriyah
Departemen Neurologi, Fakultas Kedokteran, Universitas Airlangga; RSUD Dr. Soetomo, Surabaya, Indonesia

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THE CLINICIAN'S APPROACH TO THE MANAGEMENT OF HEADACHE Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (570.967 KB) | DOI: 10.21776/ub.mnj.2016.002.02.7

Abstract

Headache is one of the most common complaints presenting to primary care physicians, as well as neurologists. Although the vast majority of headache syndromes are benign, clinicians are faced with the crucial task of differentiating benign headache disorders from potentially life threatening headache. Given the broad range of disorders that present with headache, a focused and systematic approach is necessary to facilitate the prompt diagnosis and treatment of various kinds of head pain.
ANTI ATHEROSCLEROTIC EFFECT OF ADIPONECTIN Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.162 KB) | DOI: 10.21776/ub.mnj.2015.001.02.6

Abstract

Atherosclerosis is a chronic, inflammatory disease of the arterial wall. Atherosclerosis underlies many of the common causes of cardiovascular morbidity and mortality, including myocardial infarction (MI), peripheral vascular disease, and cerebrovascular. Cardiovascular disease (CVD) has become the most frequent cause of death globally and then stroke is the second leading cause of death worldwide and a major cause of long-term disability.Recent study shows that adiponectin exhibits potent antiatherosclerotic effects. Adiponectin is a protein secreted specifically from adipose tissue. Adiponectin has a potential inhibitory effect on all molecular mechanisms of atherosclerosis.
DESIGN OF EXPERT SYSTEM AS A SUPPORT TOOL FOR EARLY DIAGNOSIS OF PRIMARY HEADACHE Azzahra, Zahwa Arsy; Purwanti, Endah; Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (708.76 KB) | DOI: 10.21776/ub.mnj.2017.003.02.5

Abstract

Background. Headache is the top ranked with 42% percentage of all complaints neurology’s patients. Focused and systematic approach is needed in making a diagnosis of primary headache type because management of headache is different for each type.Objective. Enabling users to identify the type of headache.Methods. The experiment was conducted using Naïve Bayes classifier method which is the principle is multiplying the percentage likelihood of each variable for each parameter for each class.Results. The percentage value of each parameter obtained from the data of headache patients at neurology polyclinic poly of Dr. Soetomo Hospital within 1 year from the year 2014 to 2015. The percentage value of each class likelihood sought highest value which is the output or decision-diagnosis program. Analysis of each of the input parameters, gender, age, location of head pain, headache characteristics, appeared least autonomous signs, and scale of headache may indicate that each of the options selected by the user influence the decision of the diagnosis program.Conclusion. The design of early detection of primary headaches with the input parameters as mentioned before derived from the raw data as electronic medical records to be analyzed based on methods Naïve Bayes classifier resulted in the decision diagnosis of migraine, cluster and TTH have accuracy values by 92 %.
EKSPRESI KASPASE 8 DAN PERUBAHAN JUMLAH SEL NEUROGLIA PADA REGULASI MEKANISME APOPTOSISSEL OTAK AKIBAT KERACUNAN MERKURI Paulus Sugianto, Abdulloh Machin, Hanik Badriyah Hidayati, Moh. Hasan Machfoed
NEURONA Vol 30 No. 2 Maret 2013
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION MERCURY IS A POTENT NEUROTOXIN SINCE IT INDUCES APOPTOSIS AND INFLAMMATORY RESPOND IN BRAIN CASPASES EG CASPASE 8IS ONE OF CENTRAL EFFECTORS OF APOPTOSIS AND SERVE AS SIGNALING MEDIATORS THAT ORCHESTRATE APOPTOTIC EXECUTION PATHWAYS BY CLEAVING A SUBSET OF CELLULAR PROTEINS WHEREAS BRAIN INFLAMMATORY RESPONSE IS TRIGGERED BY THE ACTIVATION OF NEUROGLIAL EG MICROGLIAL CELLS AND ASTROCYTES AND THIS GLIAL REACTIVITY HAS BEEN USED AS AN EARLY MARKER OF NEUROTOXICITYTO STUDY THE EFFECTS OF NEUROTOXICITY MERCURY WE USE CASPASE 8 AND MICROGLIAL AS A PARAMETER OF METHYL MERCURY NEUROTOXICITY
TERAPI INTERVENSI PADA NYERI KEPALA TIPE KLASTER Hanik Badriyah Hidayati,* Santoso,** Isti Suharjanti,* Mohammad Hasan Machfoed*
NEURONA Vol. 34 No. 3 Juni 2017
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

HEADACHE PREVIOUSLY KNOWN AS VARIAN OF MIGRENE IS NEUROVASCULAR HEADACHE CHARACTERIZED BY UNILATERAL HEADACHE AND ASSOCIATED WITH IPSILATERAL CRANIAL OTONOMIC SIGNS DIAGNOSIS OF CLUSTER HEADACHE IS MADE FROM HISTORY TAKING AND PHYSICAL EXAMINATION THE MAIN MANAGEMENT OF CLUSTER HEADACHE IS PHARMACOTHERAPY IN PATIENTS WITH RESISTANT CLUSTER HEADACHE REGARDING PHARMACOTHERAPY INTERVENTIONAL THERAPIES SUCH AS RADIOFREQUENCY OF PTERYGOPALATINE AND OCCIPITAL NERVE STIMULATION ARE MIGHT BE NEEDED
Tricyclic Antidepressants in Chronic Low Back Pain : A Review Ilmanita, Dzikrina; Hidayati, Hanik Badriyah
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8217

Abstract

Chronic low back pain (LBP) is the frequent chronic pain and notable health problem which is the main reason of disabling conditions, individual suffering, sick leave, and costly treatment.  Unfortunately, available therapy especially oral medicines only beneficial in no more than 50% of patients. Tricyclic antidepressants (TCAs) are commonly used for neuropathic pain but the data for neuropathic LBP is limited. The purpose of this review is to evaluate the efficacy and adverse drug reaction of TCAs in chronic LBP. We searched scientific search engines including Scopus and PubMed and collected original articles including Randomized Clinical Trial (RCT), comparative, and observational study about Tricyclic Antidepressants treatment in chronic LBP from 1998 to 2019. In this review, 5 articles and 543 patients were evaluated. All recruited articles are randomized clinical trials. Among all five relevant articles, three of them evaluate amitriptyline treatment in chronic LBP while the rest articles evaluate imipramine and nortriptyline. Amitriptyline is the most well-studied TCA for chronic LBP. We found that both amitriptyline and nortriptyline can reduce pain severity significantly when the dose is increased gradually depending on patient tolerance. TCAs can also improve disability significantly. However, single-dose imipramine is not superior than placebo. We conclude that TCAs can be effective for treating chronic LBP when used routinely for several weeks and the dose should be increased gradually depending on patient tolerance although further studies are required to confirm the optimal dose for analgesia. The most prevalence Adverse Drug Reactions (ADRs) of TCA including dry mouth, somnolence, insomnia, sedation, and constipation.
THE EFFECTS NEUROPROTECTION OF TELMISARTAN ON STROKE WITH HYPERTENSION Ernawati, Iin; Hidayati, Hanik Badriyah; ., Sumarno
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.9

Abstract

Stroke is the second deadly disease in the world after ischemic heart disease. According to data of RISKESDAS (Riset Kesehatan Dasar), stroke was the highest cause of death in Indonesia in 2013. Hypertension is the one of the most important risk factors for stroke. Hypertension therapy is done by modification and the use of antihypertensives. The antihypertensives used is Telmisartan which is a class of Angiotensin Receptor Blocker (ARB) that works by inhibiting bind to angiotensin II type receptors that is angiotensin II type 1 receptors (AT-1R) which directly make angiotensin II bind to AT-2R (angiotensin receptor type 2 receptors). Telmisartan has a neuroprotectant effect that works by inhibiting the appearance of inflammatory cytokines, production of ROS (Reactive Oxygen Species), PGE2 (prostaglandin E2) and NMDA (N-Methyl-D-Aspartate) activity. Telmisartan activates PPAR-gamma (PPAR-γ), which is very useful in carbohydrate and lipid metabolism which directly protect blood vessels. Telmisartan has the advantage of structure and pharmacokinetics that support the effects of nerve protection. Based on lipophilicity and chemical structure, Telmisartan easily penetrates the brain barrier and high affinity to PPAR-γ, supporting the effects of Telmisartan neuroprotection. Based on pharmacokinetic aspects, telmisartan has the advantage of having a rapid onset that ranges from 30-60 minutes, with T ½ (half life) elimination is 24 hours. T 1/2 elimination for up to 24 hours from Telmisartan is clinically beneficial to improve medication adherence.
MANIFESTASI NEUROPSIKIATRIK PADA LUPUS ERITEMATOSUS SISTEMIK DI RSUD DR SOETOMO SURABAYA Nadya Rinda Eka Rana,* Awalia,** Yetti Hernaningsih,*** Hanik Badriyah Hidayati****
NEURONA Vol. 36 No. 4 September 2019
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION SYSTEMIC LUPUS ERYTHEMATOSUS SLE IS A CHRONIC AUTOIMMUNE INFLAMMATORY DISEASE WITH UNKNOWN CAUSES AND EXTENSIVE CLINICAL MANIFESTATIONS AND DIVERSE DISEASE PATHWAYS THE CLINICAL MANIFESTATIONS OF SLE ARE VERY DIVERSE INCLUDING THE INVOLVEMENT OF THE NERVOUS SYSTEM AND PSYCHIATRIC SYNDROME NEUROPSYCHIATRIC
EXERCISE PREVENTS AGE-RELATED MEMORY DECLINE: THE ROLE OF NEUROTROPHIC FACTORS Rivarti, Arina Windri; Herawati, Lilik; Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 6, No 2 (2020): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.02.8

Abstract

Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.
Effectiveness of Triamcinolone and Lidocaine in Patient with Piriformis Syndrome – A Case Series Setianti, Ariani Rahayu; Hidayati, Hanik Badriyah
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

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Abstract

Piriformis syndrome (PS) has been documented as a contributory cause for sciatica, buttock, and low back pain. The worldwide incidence of PS would be about 2,4 million per year. The management of piriformis syndrome includes injection of the piriformis muscle with local anesthetic and steroid, however, the study for the effectiveness of the combination is lacking especially in Indonesian population. This case illustrates the effectiveness reduction of triamcinolone in combination with lidocaine measured by Visual Analogue Scale (VAS) in patient suffered from PS.