El-QUDWAH
El-Qudwah (04-2006)

HABBATUS SAUDAH SEBAGAI AMELIORAN FUNGSI PANKREAS PADA MENCIT DIABETES

Retno Susilowati (Fakultas Sains dan Teknologi UIN Malang)



Article Info

Publish Date
26 Jun 2012

Abstract

The aims of this study are to inventory potential of Habbatus Saudah (Nigella sativa L.) to maintain pancreas B Cells, reduced blood glucose, and increases body weight diabetic mellitus patient induced by streptozotocin (STZ). STZ as antibiotic agent has a sitotoxic effect and light carcinogenic. Injection STZ cause damages Beta cells and reduce insulin secretion.  Fifteen mice 60 days old with 30-31 grams bodyweight are separate into 4 groups: Diabetic group (D), treatment group (DH), treatment control (KH) and Blanco control (K) respectively. Diabetic rats are subcutaneous injected by streptozotocin (STZ) with dose 50 mg/bw. Treatment group added habbatus saudah seed crushed 4 g/kg feed ad libitum a week after injection, for 30 days treatment. The result shows that habbatus saudah has a potential pancreas ameliorant in mice, reduce blood glucose (p 0, 01) and increase mice bodyweight (p 0, 05). Key words: Mice, Ameliorant, Diabetic, blood glucose, bodyweight, streptozotocin, Habbatus saudah, Nigella sativa L.

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