<![CDATA[Post dural puncture headache (PDPH) mengakibatkan morbiditas pada ibu yang menjalani seksio sesarea dengan anestesi spinal. PDPH disebabkan karena penurunan tekanan intratekal akibat kebocoran cairan serebrospinalis. Bolus poligelin pada ruang epidural diharapkan secara sementara meningkatkan tekanan ruang epidural dan mengurangi kebocoran cairan serebrospinalis sehingga dapat menurunkan kejadian PDPH. Penelitian dilakukan dengan uji klinis single blind randomized controled trial pada 90 wanita hamil yang menjalani seksio sesarea dengan anestesi spinal pada Oktober sampai Desember 2011 Rumah Sakit Dr. Hasan Sadikin Bandung. Sampel dikelompokkan secara random menjadi kelompok bolus 7,5 mL poligelin dan kelompok kontrol, selanjutnya dilakukan penilaian PDPH sampai hari kelima pascaanestesi spinal. Analisis statistik berdasarkan Uji Eksak Fisher, memperlihatkan bahwa angka kejadian PDPH pada kedua kelompok perlakuan menunjukkan perbedaan bermakna secara statistik (p<0,05). Simpulan dari penelitian ini adalah bolus poligelin pada ruang epidural dapat menurunkan angka kejadian PDPH pada pasien yang menjalani operasi seksio sesarea dengan anestesi spinal.Kata kunci: Anestesi spinal, poligelin, post dural puncture headache, ruang epidural âBolus 7.5 mL Polygeline into the Epidural Space in Reducing the Incidence of Postdural Puncture Headache on Spinal AnesthesiaAbstractPost dural puncture headache (PDPH) may cause morbidity in women undergoing caesarean section with spinal anesthesia. PDPH is caused by a reduction of intrathecal pressure due to leakage of cerebrospinal fluid. Polygeline bolus into the epidural space is expected to temporarily increase the pressure of the epidural space therefore reduces cerebrospinal fluid leakage so that it may reduce the incidence of PDPH. The study conducted was a single-blind randomized clinical trial on 90 pregnant women undergoing caesarean section with spinal anesthesia from October until December 2011 in Dr. Hasan Sadikin Hospital Bandung. Samples were randomly divided into the bolus of 7.5 mL polygeline group and the control group. Evaluation of PDPH was performed until 5th day post-spinal anesthesia. Statistical analysis using Fishers Exact Test, showed that the incidence of PDPH in both treatment groups showed a statistically significant difference (p<0.05). The conclusion of this study is polygeline bolus into the epidural space may decrease the incidence of PDPH in patients undergoing caesarean section with spinal anesthesia.Key words: Epidural space, polygeline, post dural puncture headache, spinal anesthesia DOI: 10.15851/jap.v1n3.193]]>
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