<![CDATA[This study aim was to determine the immunomodulatory activity of noni (Morinda citrifolia L.) fruitextract in mice infected with Staphylococcus aureus. Mice were divided into two group : non-infected andinfected. Non Infected group was without S. aureus infection whereas the infected group was infected withS. aureus. Group contain control, dose 1 (25 mg/kg BW), dose 2 (100 mg/kg BW), and dose 3 (300 mg/kg BW).Oral treatment carried out for 20 days in every morning and each sample was injected with S. aureus atday 21 with 109 cell/mL. Relative number of T cell (CD4+, CD4+CD25+),) and cytokine interferon-ã fromCD4+ T cell (CD4+IFN-ã+) subsets was measured using the BD FACSCaliburTM Flowcytometer. Data wereanalyzed by using Analysis of Varians (p<0,05) and SPSS 16 for windows. The result showed thatadministration of noni crude extract was significantly change the relative number of CD4+, CD4+IFN-ã+,and CD4+CD25+ T cells. Treatment of noni crude extract in non-infection group could increase relativenumber of CD4+, CD4+IFN-ã+ and CD4+CD25+ T cells that might be caused by active compounds of noni asmitogen. Giving of noni crude extract in infected group could reduce the relative number of CD4+, CD4+CD25+and CD4+IFN-ã+ T cells due to it active compounds as anti-inflamation. Noni fruit extract can be used aspreventive therapy on S. aureus infection because it contains active compounds as an anti-inflammationeffect.]]>
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