Indonesian Journal of Pharmaceutical and Clinical Research
Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research

Determination of Dexamethasone in Unregistered Herbal Weight Gain Using HPTLC-Densitometry

Asra, Ridho (Unknown)
Zulharmita (Unknown)
Yuliatim, Nopitri (Unknown)

Article Info

Publish Date
31 Dec 2018

Abstract

A method was described for the simultaneous determination of dexamethasone in herbal weight gain. Three unregistered herbal weight gains (sample A, B, and C) were analyzed by using HPTLC-densitometry method. Samples were extracted as bases into methanol, separated by HPTLC silica gel 60 F254plate using chloroform: methanol (9:1) as mobile phase followed by densitometry measurement of its spot. The result showed that the detector response was linear for concentrations between 100-500 mg/mL (r =0.998). The limits of detection and quantitation were 9.19 mg/mL and 30.64 mg/mL, respectively. Dexamethasone contents from samples were analyzed. The result showed that two samples (sample A and B) were positively containing dexamethasone and the other one showed a negative result. The average contents of dexamethasone from both samples were 0.23% and 0.25%, respectively.

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Journal Info
Indonesian Journal of Pharmaceutical and Clinical Research
Website

Abbrev

idjpcr

Publisher

Universitas Sumatera Utara

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical ...