The Journal of Experimental Life Sciences (JELS)
Vol. 9 No. 1 (2019)

Role of Active Compounds of Bohadschia argus Inhibit Cancer Cell Survival

Jantje Wiliem Souhaly (University of Brawijaya)
Sri Rahayu (University of Brawijaya)
Widodo Widodo (University of Brawijaya)

Article Info

Publish Date
22 Mar 2019

Abstract

Sea cucumber is marine biota with a high economic value and also has potential for anti-cancer. The purpose of this study was to explore the mechanism of active compound of Bohadschia argus on regulating cancer cell survival. The B. argus samples were collected from the sea of Kamal Village, West Seram Maluku, then extracted by water. The constituents of water extract of B. argus were examined by LC-MS. The network among active compound and its protein target were determined by Cytoscape app. The result shows that B. argus has several active compounds, such as chondroitin sulfate, holothurin A, holothurin B, and scabraside that might play a role in cancer cell apoptosis, proliferation, and metastasis. Keywords: Active compound, Bohadschia argus, LC-MS.

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Journal Info
The Journal of Experimental Life Sciences (JELS)
Website

Abbrev

jels

Publisher

Universitas Brawijaya

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

Description

The Journal of Experimental Life Science (JELS) is a scientific journal published by Postgraduate School, University of Brawijaya as distribution media of Indonesian researcher’s results in life science to the wider community. JELS is published in every four months. JELS published scientific ...