Jurnal Medika Veterinaria
Vol 13, No 2 (2019): J. Med. Vet.

39. Efficacy of Jatropha cream (Jatropha curcas L.) on maturation phase of cutaneus healing process in Mice (Mus Musculus)

Abdul Harris (Laboratorium Farmakologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Cut Mentari Fatihah Amran (Program Studi Pendidikan Dokter Hewan, Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
M. Nur Salim (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Ummu Balqis (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
T. Armansyah (Laboratorium Farmakologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
T. Fadrial Karmil (Laboratorium Klinik Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Ginta Riady (Laboratorium Reproduksi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)



Article Info

Publish Date
16 Feb 2020

Abstract

This study aims to determine the efficacy of jatropha curcas L. cream in the maturation phase of healing of mice leather injuries. This study used nine rats with 3 treatments, ie treatment group I smeared cream base (P1), treatment group II smeared 0.1% sulfadiazine cream (P2) and treatment group III smeared jatropha curcas 10% (P3). The result of ANAVA test of treatment I, treatment II and treatment III had significant effect (P 0,05) on fibroblast cells but each treatment group on collagen density level showed significant effect (P 0.01). Duncan test results on fibroblasts, P3 was significantly different (P 0.05) with P2 and P3, whereas the results on P3 collagen density were significantly different (P 0.01) with P2 and P1. The conclusion that 10% jatropha gum cream for 10 days can decrease the number of fibroblast cells and increase the amount of collagen thus accelerate the process of maturation phase of healing of mice leather injuries.

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