Jurnal Ilmu Kedokteran (Journal of Medical Science)
Vol 13, No 1 (2019): Jurnal Ilmu Kedokteran

Immunosenescence : Penuaan Pada Sel Makrofag

Fajri Marindra Siregar (KJF Biokimia, Fakultas Kedokteran, Universitas Riau, Jl. Diponegoro No 1, Pekanbaru, Indonesia, Email : fajrifkunri@gmail.com)

Article Info

Publish Date
01 Mar 2019

Abstract

Immune function will decrease with age. The weakening of immune system is known as immunosenescence. Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergo aging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomere shortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decrease number of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changing macrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissue regeneration.

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Journal Info
Jurnal Ilmu Kedokteran (Journal of Medical Science)
Website

Abbrev

jik

Publisher

Universitas Riau

Subject

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

Description

Journal of Medical Science receives a script from health and medical lecturer, undergraduate, residents, hospital staff and those who interested in writing scientific papers. The scientific articles posted on JIK include: literature reviews, research article, case report and EBCR (Evidence Based ...