Jurnal Farmamedika (Pharmamedica Journal)
Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)

PERBANDINGAN INHIBISI α-MANGOSTIN, β-MANGOSTIN, DAN γ-MANGOSTIN TERHADAP PROTEIN AKT-KINASE PADA SEL KANKER PANKREAS SECARA MOLECULAR DOCKING

Harry Noviardi (Sekolah Tinggi Teknologi Industri dan Farmasi Bogor)
Armi Wulanawati (Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor)
Muhamad Sholehuddin Malik Ibrohim (Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor)

Article Info

Publish Date
12 Jun 2016

Abstract

The mangosteen pericarp contains a class of compounds called xanthones, including α-mangostin, β-mangostin, and, γ-mangostin. Mangosteen products have become popular natural medicine. cancer is a malignant tumor types are particularly deadly caused by proliferative effects to inhibit apoptosis cell. Akt protein is considered to be the key downstream effector of reducing apoptosis. This study aims to determine the ratio of the potential of α-mangostin, β-mangostin, γ-mangostin as inhibitors of Akt protein of pancreatic cancer cells by the Gibbs free energy (ΔG), inhibition constants, hydrogen interactions. The computationally study using molecular docking method.Based on the analysis docking, γ-mangostin provides the potential for better inhibition than gemcitabine.

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Journal Info
Jurnal Farmamedika (Pharmamedica Journal)
Website

Abbrev

farmamedika

Publisher

Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

Description

Jurnal Farmamedika dikelola oleh Lembag Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Teknologi Industri dan Farmasi Bogor. Frekuensi penerbitan jurnal sebanyak 2 kali dalam satu tahun pada bulan Juni dan Desember. Kategori tulisan berupa hasil penelitian dari peneliti maupun akademisi dalam ...