e-Journal Pustaka Kesehatan
Vol 6 No 2 (2018)

Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin

Ongky Dyah Anggraini (Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Jember)
Cicih Komariah (Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Jember)
Aris Prasetyo (Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Jember)



Article Info

Publish Date
04 May 2018

Abstract

Mango is a plant contains many active compounds with health benefits. Total phenolic content of mango peel is higher than mango flesh, with its major component are mangiferin and quercetin. Quercetin has anti-inflammatory effects through the inhibition of inflammatory mediators are serotonin, bradykinin, histamine and prostaglandin, possibly could reduce oedema as a sign of inflammation. This study used carrageenin to induce inflammation by making paw oedema in mice. The aim of this research was to know the effect of arumanis mango peel extract to reduce paw oedema in white male mice. The was quasi experimental study with 7 study groups. Spearman analyses showed a correlation with significance of (p= 0.003) that mean it has a significant correlation (p <0.01) at the 330th min. Spearman correlation coefficients was 0,632, indicated that the dose of extract and paw oedema have strong correlation. It can be concluded that mango peel extract has effect for reducing paw oedema in white male mice, with the smallest dose was 1,002mg / gBW. Keywords: mango, quercetin, paw oedema

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Journal Info

Abbrev

JPK

Publisher

Subject

Health Professions Library & Information Science

Description

e-Journal “Pustaka Kesehatan” merupakan jurnal elektronik ilmiah berISSN (ISSN: 2355-178X) yang menerbitkan artikel hasil penelitian di bidang kesehatan secara umum meliputi: Kedokteran, Kedokteran Gigi, Kesehatan Masyarakat, Farmasi, dan Ilmu Keperawatan. Artikel yang dikirim belum ...