Jurnal Farmasi Sains dan Komunitas (JFSK)
Vol 15, No 1 (2018)

HEPATOPROTECTIVE EFFECT OF FOREST HONEY ON CARBON TETRACHLORIDE INDUCED FEMALE WISTAR RATS

Yunita Linawati (Faculty of Pharmacy, Universitas Sanata Dharma)



Article Info

Publish Date
31 May 2018

Abstract

Hepatoprotective effect study of forest honey had been conducted on a female rat induced with carbon tetrachloride (CCl4). The study aimed at obtaining the scientific data and the evidence of forest honey as hepatoprotective agent on the rat. The study was a true experimental study with a single factor completely randomized design. Thirty rats were randomly divided into six groups (n=5). Group I received carbon tetrachloride 2.0 mL/kgBW intraperitoneally, group II received olive oil 2.0 mL/kgBW intraperitoneally, group III received forest honey 8.1 mL/kgBW (6 days, peroral), groups IV, V, VI were given forest honey 3.6, 5.4, 8.1 mL/kgBW (6 days, peroral) and intraperitoneal induction of carbon tetrachloride 2 mL/kgBW on seventh day. The blood sample of all rats were taken for ALT-AST measurement and their liver were sampled for histological examination of the liver cell. Groups I and III on the seventh day, group II on the second day, groups IV,V,VI on the eighth day. The result showed that a forest honey can be used as a hepatoprotective agent on the female rat Wistar strain induced by carbon tetrachloride 2 mL/kgBW with doses 3.6, 5.4, 8.1 mL/kgBW.

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Journal Info

Abbrev

JFSK

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical ...