Yunita Linawati
Faculty Of Pharmacy, Universitas Sanata Dharma

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RISIKO KARDIOVASKULAR BERDASARKAN FAKTOR JAMINAN KESEHATAN PADA MASYARAKAT PEDESAAN DI KABUPATEN SLEMAN YOGYAKARTA Suhadi, Rita -; Linawati, Yunita; Virginia, Dita Maria; Setiawan, Christianus Heru
Jurnal Kedokteran Brawijaya Vol 29, No. 4 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.04.10

Abstract

Penyakit kardiovaskular merupakan risiko kesehatan terbesar di Indonesia. Penelitian survei cluster random sampling tahun 2015, program jaminan kesehatan berhasil meningkatkan kesadaran dan terapi pada subjek dengan tekanan darah ?140/90mmHg di Kabupaten Sleman Yogyakarta. Penelitian ini bertujuan untuk mengevaluasi risiko kardiovaskular terkait program jaminan kesehatan. Penelitian ini merupakan survei potong lintang analitik dan subanalisis pada subjek yang dapat dihitung risiko kardiovaskular 10 tahun ke depan menggunakan skor Framingham. Penelitian dilakukan pada subjek berumur 30-74 tahun dan menandatangani informed-consent. Subjek dikelompokkan berdasarkan dengan atau tanpa jaminan kesehatan. Data rerata umur, body mass index (BMI), tekanan darah, dan skor Framingham dianalisis dengan uji-t (p<0,05), sedangkan tingkatan risiko kardiovaskular 10 tahun ke depan dianalisis menggunakan statistik chi-square.  Dari penelitian ini ditemukan sebanyak 64,6% dari 429 subjek memiliki jaminan kesehatan dalam beberapa sistem jaminan. Parameter observasi kelompok dengan dan tanpa jaminan kesehatan tidak berbeda bermakna (p>0,05) untuk variabel umur, gender, merokok, pendidikan, tekanan darah, hiperglikemia, dan BMI. Subjek dengan dan tanpa jaminan kesehatan berturut-turut memiliki tekanan darah sistolik 156,5 (22,2) mmHg berbanding 156,4 (20,0) mmHg dan skor Framingham 18,4 (9,3)% berbanding 19,2 (9,3)% (p>0,05) yang termasuk kategori risiko kardiovaskular sedang. Pada subkelompok subjek dengan tekanan darah ?140/90 mmHg (n=347, 80,9%) subjek dengan jaminan kesehatan (n=277, 53,2%) dan tanpa jaminan kesehatan memiliki skor Framingham yang tidak berbeda bermakna, namun berbeda kategori risikonya yaitu 19,8 (8,9)% kategori risiko sedang berbanding 21,1 (8,3)% kategori risiko tinggi. Kesimpulan, jaminan kesehatan belum terbukti menurunkan secara bermakna risiko kardiovaskular subjek di pedesaan di Sleman-Yogyakarta.
HEPATOPROTECTIVE EFFECT OF FOREST HONEY ON CARBON TETRACHLORIDE INDUCED FEMALE WISTAR RATS Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.692 KB) | DOI: 10.24071/jpsc.00983

Abstract

Hepatoprotective effect study of forest honey had been conducted on a female rat induced with carbon tetrachloride (CCl4). The study aimed at obtaining the scientific data and the evidence of forest honey as hepatoprotective agent on the rat. The study was a true experimental study with a single factor completely randomized design. Thirty rats were randomly divided into six groups (n=5). Group I received carbon tetrachloride 2.0 mL/kgBW intraperitoneally, group II received olive oil 2.0 mL/kgBW intraperitoneally, group III received forest honey 8.1 mL/kgBW (6 days, peroral), groups IV, V, VI were given forest honey 3.6, 5.4, 8.1 mL/kgBW (6 days, peroral) and intraperitoneal induction of carbon tetrachloride 2 mL/kgBW on seventh day. The blood sample of all rats were taken for ALT-AST measurement and their liver were sampled for histological examination of the liver cell. Groups I and III on the seventh day, group II on the second day, groups IV,V,VI on the eighth day. The result showed that a forest honey can be used as a hepatoprotective agent on the female rat Wistar strain induced by carbon tetrachloride 2 mL/kgBW with doses 3.6, 5.4, 8.1 mL/kgBW.
EFEK PEMBERIAN JUS BUAH PISANG KEPOK (Musa paradisiaca forma typica) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG TERBEBANI GLUKOSA F. Eki Supra Bawati; Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.236 KB) | DOI: 10.24071/jpsc.0094

Abstract

Abstract: This research aimed to determine the effects of administration of Musa paradisiacaforma typica juice on blood glucose levels and determine what dose of Musa paradisiaca formatypica juice which is most effective for lowering blood glucose levels in rats burdened glucose.This research was experimental with study with one way complete design using 25 male rats weredivided into five groups. Group I (negative control) was given CMC 1%, group II (positivecontrol) was given Glibenclamide dose of 0,64 mg/kgBW and group III, IV, V the rats were given5; 10; 20 mL/kgBW dose of Musa paradisiaca forma typica juice, all of the processes were giventhrough the oral method. Hypoglycemic effect of Musa paradisiaca forma typica juice was testedby following the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents weretaken, at the 0 minutes before the OGTT and also taken at minutes of 15, 30, 60, 90, 120, 180, and240 after the OGTT, from the tested animal that had been gotten the pre-treatment of the negativecontrol, positive control and Musa paradisiaca forma typica juice before. Data of blood glucoselevels was statistically analyzed using one way ANOVA and Scheffe test with 95% convidencelevel. The result of this research showed that Musa paradisiaca forma typica juice can loweringblood glucose levels on rats in burdened glucose. Dose Musa paradisiaca forma typica juice aremost effective in lowering blood glucose levels in a dose was 10 mL/kgBW.Key words: Musa paradisiaca forma typica, blood glucose levels, OGTT
PENGARUH PEMBERIAN MADU HUTAN TERHADAP PROLIFERASI LIMFOSIT PADA HEWAN UJI TIKUS JANTAN GALUR WISTAR Kartika Sari Senas; Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.627 KB) | DOI: 10.24071/jpsc.0075

Abstract

Abstract: Forest honey is produced by wild bees by taking nectars from several kinds of plant.One of active chemicals contained within honey is flavonoid. It is believed as animmunomodulator due to it has role in fighting against free radicals and increasing body immunesystem against disease infection. This research aimed to understand the influences of foresthoney administration to the lymphocyte proliferation on male mice Wistar family. This researchis a pure, experimental with one way, random research design. Total of 20 rats was divided into 4groups. Each group was given honey forest with dose of 0,27; 0.54; 1.08 mL/200 g BW, andnegative control group was given aquadest 2.5 mL/200 g BW. The lymphocyte proliferation ismeasured from the amount of lymphocyte based on Optical Density (OD) values, the read onELISA reader at the wavelength of 550 nm. The result shown that the administration of foresthoney has effect on significance increase the lymphocyte proliferation (p0.05) than negativecontrol on male mice Wistar family.Key words : Foresthoney, lymphocyte proliferation, immunomodulator
Hubungan antara Pengetahuan, Sikap, dan Tindakan Gaya Hidup Sehat dengan Risiko Penyakit Kardiovaskular pada Orang Dewasa di Pedesaan di Daerah Istimewa Yogyakarta Aris Widayati; Fenty Fenty; Yunita Linawati
Indonesian Journal of Clinical Pharmacy Vol 8, No 1 (2019)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.95 KB) | DOI: 10.15416/ijcp.2019.8.1.1

Abstract

Sindrom metabolik (SM) merupakan salah satu faktor risiko penyakit kardiovaskular (PKV). Gaya hidup tidak sehat cenderung meningkatkan kejadian SM dan PKV. Masyarakat pedesaan mempunyai akses sumber informasi tentang gaya hidup sehat yang relatif terbatas. Oleh karena itu, penelitian ini bertujuan mengeksplorasi hubungan antara pengetahuan, sikap, dan tindakan (PST) terkait gaya hidup sehat dengan risiko PKV di kalangan masyarakat pedesaan di D.I. Yogyakarta. Jenis penelitian ini adalah observasional analitik dengan desain potong lintang. Sampel penelitian direkrut secara non-random purposive di dua dusun yaitu Tanjung dan Dlingseng, Desa Banjaroyo, Kecamatan Kalibawang, Kabupaten Kulonprogo, D.I. Yogyakarta. Kriteria inklusi responden yaitu penduduk dewasa sehat berusia 30–75 tahun. Kriteria eksklusi yaitu wanita hamil dan responden yang datanya tidak lengkap. Data dikumpulkan pada Bulan Mei–Juni 2018. Data pengetahuan, sikap, dan tindakan terkait gaya hidup sehat (PST) dikumpulkan menggunakan kuesioner. Data faktor risiko PKV yaitu indeks massa tubuh (IMT), lingkar pinggang (LP), tekanan darah (TD), kadar gula darah puasa (GDP), dan kolesterol total (Chol) diperoleh melalui pengukuran. Data dianalisis secara deskriptif korelatif dengan Spearman correlation. Sebanyak 124 data responden dianalisis. Sebanyak 56,5% responden mempunyai tingkat pengetahuan tinggi, 66,1% sikap positif, dan 67,7% melakukan tindakan hidup sehat. Sebanyak 55,6% IMT responden termasuk obes general; 65% ukuran LP wanita dan 25% LP pria termasuk obes sentral; median TD sistol di atas normal dan diastol normal; median GDP dan kolesterol normal. Hasil yang diharapkan adalah PST dan faktor risiko PKV berkorelasi negatif. Namun, hasil analisis menunjukkan beberapa faktor risiko PKV berkorelasi positif dengan PST. Hal ini kemungkinan disebabkan oleh faktor social desirability bias, the phenomenon of intention not translated into action, dan recall bias pada pengukuran pengetahuan, sikap, dan tindakan.Kata kunci: Gaya hidup sehat, kardiovaskular, pedesaan, pengetahuan, sikap, tindakanAssociation between Knowledge, Attitude, and Practices of Lifestyle to Cardiovascular Disease Risk Factors among Adults in Rural Area of Yogyakarta, IndonesiaAbstractMetabolic syndrome (MS) is one of risk factors of cardiovascular disease (CVD). Unhealthy lifestyle tends to elevate the risk of MS. People in rural area might not have adequate access to information on healthy lifestyle. Hence, this study aimed to explore association between knowledge, attitude, and practices (KAP) on healthy lifestyle and cardiovascular (CVD) risk factors among rural adults in Yogyakarta Province. This is an observational analytic study with cross sectional design. Samples were recruited purposively in two sub-villages, i.e.: Tanjung and Dlingseng in Banjaroyo, Kalibawang, Kulonprogo. Inclusion criteria were healthy adult people in between 30 to 75 years old. Those who were pregnant and those who did not complete the data were excluded. Data collection was conducted during May to June 2018. Data on KAP were gathered using a questionnaire. Data on CVD risk factors were collected through measurements of body mass index (BMI), waist circumference (WC), blood pressure (BP), fasting blood glucose (FBG), and total cholesterol (Chol). Data were analyzed descriptively using Spearman correlation. Of the 124 respondents, 64.5% were female, 56.5% have high level of knowledge, 66.1% have positive attitude, and 67.7% have healthier lifestyle practices. The profiles of CVD risk factors are as follows: 55.6% are general obese; 65% of female’s WC and 25% of male’s WC are central obese; median systole is high, but diastole is normal; median FBG and Chol are normal. In this study, some of the risk factors have positive correlation with KAP. This might be caused by social desirability bias, the phenomenon of intention not translated into action, and recall bias in the KAP measurements.  Keywords: Attitude, CVD risk factors, healthy lifestyle, knowledge, practice, rural
Pengetahuan dan Profil Gaya Hidup Sehat pada Orang Dewasa di Pedesaan di Daerah Istimewa Yogyakarta Aris Widayati; Fenty Fenty; Yunita Linawati; Putu Dyana Christasani
Indonesian Journal of Clinical Pharmacy Vol 9, No 2 (2020)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2020.9.2.118

Abstract

Kejadian sindrom metabolik (SM) dan penyakit kardiovaskular (PKV) dipengaruhi oleh gaya hidup sehat sehari-hari. Penelitian ini bertujuan mengeksplorasi profil gaya hidup sehat dan pengetahuan tentang hidup sehat dengan pemberian intervensi edukasi di kalangan masyarakat pedesaan di D.I. Yogyakarta. Penelitian ini bersifat eksperimental semu dengan desain potong lintang. Variabel yang diteliti adalah profil gaya hidup sehat dan pengetahuan tentang gaya hidup sehat sebelum dan setelah edukasi tentang gaya hidup sehat. Sampel penelitian dipilih secara non-random purposive dengan kriteria inklusi yaitu penduduk dewasa sehat, di dua dusun yaitu Tanjung dan Dlingseng, Desa Banjaroyo, Kecamatan Kalibawang, Kabupaten Kulonprogo, D.I. Yogyakarta. Data dikumpulkan pada bulan Juli–Agustus 2019 dengan kuesioner yang telah diujicoba, kemudian dianalisis secara deskriptif dan komparatif. Sebanyak 108 responden berpartisipasi dalam penelitian ini. Sebagian besar responden merupakan perempuan (63,9%), median usia 54 tahun (rentang: 27–76 tahun), dan memiliki tingkat pendidikan tergolong rendah (82,4%). Profil gaya hidup sehat secara umum baik, yaitu lebih dari 50% responden tidak merokok, aktif secara fisik, tidak minum alkohol, menu harian rendah glukosa, rendah kolesterol, dan tinggi serat sayur dan buah. Sebanyak 64,1% responden mempunyai tingkat pengetahuan tentang gaya hidup sehat pada kategori tinggi. Namun, variabel tingkat pengetahuan tidak berasosiasi dengan semua variabel profil gaya hidup sehat, kecuali variabel aktivitas fisik. Edukasi mampu meningkatkan pengetahuan secara signifikan dengan rata-rata skor sebelum edukasi 7,0, setelah edukasi 8,0, dan satu bulan setelah edukasi 9,0 (p=0,000). Edukasi penting dilakukan untuk menjamin keberlanjutan gaya hidup sehat tersebut.Kata kunci: Gaya hidup sehat, intervensi edukasi, kardiovaskular, pedesaan, pengetahuan Knowledge and Profiles of Healthy Lifestyle among Adults in Rural Area of Yogyakarta Province Indonesia AbstractMetabolic syndrome (MS) and cardiovascular diseases (CVD) are influenced by healthy lifestyle. The purpose of this study is to explore healthy lifestyle profiles and knowledge amongst the rural inhabitants of D.I. Yogyakarta, through education intervention. This is a quasi-experimental research with cross-sectional design, and the observed variables include healthy lifestyle and knowledge before and after the intervention. In addition, samples were selected by non-random purposive technique, and the inclusion criteria were adults living in the predetermined villages of Tanjung and Dlingseng, Banjaroyo, Kalibawang, Kulonprogo, D.I. Yoyakarta. The data were collected from July to August 2019 using a pre-tested questionnaire, prior to analysis with descriptive and comparative statistics. A total of 108 respondents participated in this study, comprising majorly females (63.9%), with a median age of 54 years (range: 27–76 years old), while 82.4% were in the lower education level. The results show a generally good healthy lifestyle profiles, as over 50% of respondents had no history of smoking and alcohol consumption. Also, most participants had a good level of physical activity, low glucose and cholesterol, alongside a high consumption of fiber foods from fruits and vegetables. In addition, about 64.1% of respondents had substantial related knowledge, despite the absence of any significant associations with all variables, except physical activity. The levels of knowledge significantly differed between before and after education intervention, evidenced by mean scores of 7.0 and 8.0, respectively. Furthermore, 9.0 was recorded at one month after (p=0.000), thus intervention was considered important, especially to maintain healthy habits.Keywords: Education, healthy life style, knowledge, rural
Frekuensi Genotip dan Alel Gena Sulfonylurea Receptor-1 (sur1) pada Subjek Diabetes Melitus Tipe 2 Suku Jawa YUNITA LINAWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.716 KB)

Abstract

Type 2 diabetes is a metabolic disorder that results from insulin secretion disorder, insulin action or both. SUR1 gene is part of KATP channel in the pancreatic β-cell that plays an essential role related with cell membrane depolarization and glucose-induced insulin secretion. The polymorphism p.R1273R of SUR1 gene, causes KATP channel failed to give feedback to metabolic activation, failed of closing KATP channel, reduces insulin secretion, impaired glucose tolerance, and causes type 2 diabetes. This is case-control study using 80 subjects consist of 40 subjects with type 2 diabetes as case and 40 subjects of non diabetes as control. The SUR1 gene p.R1273R polymorphism genotyping were detected by PCRRFLP. Data were statistically analyzed by t-test, Chi-Square. The genotype frequency distribution of p.R1273R SUR1 gene in type 2 diabetes subjects were 90% of GG genotype and 10% of AG genotype. In non diabetes subjects, GG genotype was 87,5% and AG genotype was 12.5%. In type 2 diabetes and non diabetes subjects the AA genotype was not observed. The allele frequency distribution in type 2 diabetes subjects G allele was 95% and A allele was 5%, in non diabetes subjects G allele was 93.75% and A allele was 6.25%. All the genotype and allele frequency distributions in type 2 diabetes and non diabetes subjects were not statistically significant (p = .723 genotype frequency; p = 0.732 allel frequency).