Journal of Tropical Biodiversity and Biotechnology
Vol 5, No 3 (2020): December

Antihyperglycemic and Antioxidant Activity of Nanoemulsion Extracts of M. affine D. Don Leaves in Alloxan-Induced Rat

Safrida Safrida (Department of Biology Education, Faculty of Teacher Training and Education, Syiah Kuala University)
Khairil Khairil (Department of Biology Education, Faculty of Teacher Training and Education, Syiah Kuala University)
Fani Fardinita (Department of Biology Education, Faculty of Teacher Training and Education, Syiah Kuala University)

Article Info

Publish Date
14 Dec 2020

Abstract

This study determined the antihyperglycemic and antioxidant activity of nanoemulsion extracts of M. affine leaves in alloxan-induced rats. This research used 24 male Wistar rats around three months old which grouped as normal (untreated), negative control (treated with carboxymethyl cellulose sodium/Na-CMC,), positive control (treated with glibenclamide), and various concentration (30, 60, and 90%) of nanoemulsion extract of M. affine leaves groups. The extract of M. affine leaves had an antioxidant activity with IC50 5.30 ppm, categorized as a very strong antioxidant. Furthermore, the administration of this extract decreased glucose levels in antihyperglycemic rats.  We concluded that M. affine leaves extract potential as antioxidants and be developed as an ingredient for diabetic drugs.

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Journal Info
Journal of Tropical Biodiversity and Biotechnology
Website

Abbrev

jtbb

Publisher

Universitas Gadjah Mada

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

Description

Journal of Tropical Biodiversity and Biotechnology (JTBB) is an authoritative source of information concerned with the advancement of tropical biology studies in the Southeast Asia Region. It publishes original scientific work related to a diverse range of fields in tropical biodiversity, functional ...