<![CDATA[Background: Chemotherapy induced Alopecia (CIA) is one of the most complained and cause the highest distress in breast cancer patients with chemotherapy. Cryotherapy or Scalp Cooling is an alternative intervention to reduce metabolism of cytotoxic agents against hair follicle by lowering the temperature of the scalp. Literature that discusses the effectiveness of Cryotherapy in breast cancer patients is still limited.Objective: Summarize and investigate the effect of Cryotherapy on preventing Chemotherapy induced Alopecia in breast cancer patients and its determinant factors of successfull Cryotherapy . Design: Literature ReviewData Sources: A search was performed by using Ebscohost, Scopus, Science Direct, and ProQuest database from 2009 to 2019 for research article.Review methods: A systematic process was used to analyze and extract data include studies using CASP.Result: From 278 articles that have been observed using CASP, only 10 articles match the inclusion criteria. Total respondents in 10 articles were 1201 breast cancer patients undergoing chemotherapy. All articles used in this study showed positive results about the effect of Cryotherapy on decreasing the severity of Chemotherapy Induced Alopecia (CIA) measured by hair preservation, hair loss, hair regrowth, and decreasing use a wig or head covering. The importance of continuously monitoring the patient's condition to manage the side effects caused by Cryotherapy such as headaches, cold, and nausea.Conclusion:Cryotherapy significantly reduce the severity of CIA by inhibit the process of mitosis and vasoconstriction. There are several factors that must be considered when giving Cryotherapy, such as type of chemotherapy, dosages, device, duration of administration, and temperature. For further research, it is important to considered some factors that can affect the successfull of Cryotherapy and the patient response]]>
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