VALENSI
Jurnal Kimia VALENSI Volume 6, No. 2, November 2020

Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines

Tri Mayanti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia)
Nur Insani Amir (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia)
Dewa Gede Katja (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Kampus Kleak, Manado, 95115, North Sulawesi, Indonesia)
Sofa Fajriah (Research Central for Chemistry, Indonesian Science Institute, PUSPITEK, Serpong, 15320, Tangerang, Indonesia)
Ahmad Darmawan (Research Central for Chemistry, Indonesian Science Institute, PUSPITEK, Serpong, 15320, Tangerang, Indonesia)
Unang Supratman (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Sumdeang, Indonesia)
Khlaijah Awang (Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia)
Yoshihito Shiono (Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan)

Article Info

Publish Date
01 Dec 2020

Abstract

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.

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Journal Info
VALENSI
Website

Abbrev

valensi

Publisher

Universitas Islam Negeri Syarif Hidayatullah Jakarta

Subject

Chemistry

Description

Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of ...