Natural Sciences Engineering and Technology Journal
Vol. 1 No. 1 (2021): Natural Sciences Engineering and Technology Journal

Genetics in Colorectal Cancer: A Narrative Literature Review

Billy Peter Manawan (Department of Surgery, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)

Article Info

Publish Date
13 Aug 2021

Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed form of cancer globally, which is about 11% of all cancer diagnoses. Obesity, together with kind of sedentary lifestyle, red meat consumption, tobacco, and alcohol consumption are considered as predisposing factors of progression of CRC. This literature review was aimed to describe genetic aspect in colorectal cancer. In the development of colorectal cancer, genetic factors having a role in its incidence. The hereditary type of colorectal cancer was divided into two types is polyposis and Lynch syndrome which have each and different mechanism and genetic pattern. Lynch syndrome contributes to 3–5% of CRC cases and is caused by a germline mutation in one of four genes associated with the DNA mismatch repair (MMR) system; MLH1, MSH2, MSH6, or PMS2. In polyposis, there are some types such as familial adenomatous polyposis (FAP) which is mostly caused by APC mutation, MYH-associated polyposis, and the rare hamartomatous polyposis syndromes. In conclusion, genetic testing and better family history documentation can enable those with a hereditary predisposition for the neoplasm to take preventive measures.

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Natural Sciences Engineering and Technology Journal
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nasetjournal

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HM Publisher

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Aerospace Engineering Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Energy Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Social Sciences Transportation

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Natural Sciences Engineering and Technology Journal (NASET Journal) concern with publishing the original research articles, review articles from contributors, and the current issues related to engineering, technology, and natural sciences. The main objective of NASET Journal is to provide a platform ...