<![CDATA[Background: Systemic Lupus Erythematosus (SLE) disease is an evolutionary systemic disease affecting one or several organs of the body, such as the kidneys, skin, blood cells and blood system. In sick children, in addition to maintaining growth and development, fulfilling nutritional needs is very useful for accelerating the healing process, shortening the treatment period, reducing the occurrence of complications, reducing morbidity and mortality and preventing malnutrition due to medication or medical action. The purpose of this case is to report a case in Semarang and conduct a discussion of Systemic Lupus Erythematosus cases and the complication so that proper treatment can immediately start.Case Presentation: a 10-year-old girl came complaining of difficulty walking, patient's face was also swollen. Patients with a history of SLE, lupus nephritis, normotension on control, and had undergone 4 times CPA treatment but stopped since March 2020. The patient will continue the 2nd month of Cyclophosphamide (CPA) treatment, but the laboratory examination results show proteinuria +3, the patient also found good nutrition, short stature, and underweight, patient advised to be hospitalized.Conclusion: The patient was diagnosed with SLE, lupus nephritis, normotension on control, short stature, and underweight. Patients receive therapy in the form of methylprednisolone, CPA, anti-hypertensive supportive therapy and management of underweight and short stature children due the medication. ]]>
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