Majalah Patologi Indonesia
Vol 30 No 3 (2021): MPI

Korelasi Ekspresi PD-L1 dengan TILs CD8+ pada Kanker Paru Jenis Karsinoma Bukan Sel Kecil

Erisca Ayu Utami (Unknown)
Ika Kartika Ika Kartika (Unknown)
Suly Auline Rusminan (Unknown)
Erial Bahar Erial Bahar (Unknown)
Krisna Murti Krisna Murti (Unknown)



Article Info

Publish Date
27 Sep 2021

Abstract

BackgroundNon-small cell lung cancer (NSCLC) is an epithelial carcinoma of the lung which consists of adenocarcinoma, squamous cellcarcinoma (SCC), and large-cell carcinoma (LCC). In a microtumor environment, PD-L1 and PD-1 bonds are immune checkpointsthat act in suppressing the activity of CD8+ TILs, thus affecting the prognosis of NSCLC. Aims of this study is to determine thecorrelation between PD-L1 expression with CD8+TILs in NSCLC.MethodsThis was a cross-sectional study of NSCLC registered in Department of Anatomical Pathology Faculty of Medicine University ofSriwijaya/Dr. Moh. Hoesin Palembang Hospital since 1 January 2017 to 31 January 2020 with a total of 24 samples. All sampleswere immunostained using PD-L1 and CD8 antibodies. PD-L1 expression was assessed in tumor mass and CD8 expression inintratumoral and peritumoral TILs.ResultsOnly two subtypes, adenocarcinoma and SCC, were found in this study. Adenocarcinoma was the most frequent subtype (54.1%),sample group is dominated by <60 years old and was the subtype that expressed the PD-L1 most strongly (TPS ≥50%). There wasnot significant correlation between PD-L1 expression with CD8+ TILs in NSCLC (p=0.679 and p=0.826) but based onclinicopathological characteristics, there was a significant relationship between PD-L1 with disease stage and between intratumoralCD8+ TILs density with disease stage (p=0.048 and p=0.017).ConclusionAdenocarcinoma subtype had stronger expression of PD-L1 compared to SCC. There was no correlation between PD-L1 and CD8+TILs density in NSCLC.

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Journal Info

Abbrev

patologi

Publisher

Subject

Health Professions Public Health

Description

Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara ...