Indonesian Journal of Medical Sciences and Public Health
Vol 1 No 1 (2020)

Usage of Inhaled Nitric Oxides in Cases of Eisenmenger Syndrome

Nenny Triastuti (Department of Pharmacology, Medical Faculty of University Muhammadiyah of Surabaya 60113, Indonesia)
Muhammad Perdana Airlangga (Cardiology Department Medical Faculty of University Muhammadiyah of Surabaya)
Muhammad Anas (Obstetric Gynecologic Department Medical Faculty of University Muhammadiyah of Surabaya)



Article Info

Publish Date
30 Jun 2020

Abstract

Eisenmenger Syndrome is congenital heart disease with pulmonary hypertension and shunting turning from right to left. The resistance of pulmonary vascular more than 7.5 mmHg/L/min. The right ventricle and pulmonary artery always enlarge. Physiological effects of inhaled nitric oxide therapy cause selective pulmonary vasodilation: Hypoxia alveoli causes reversible vasoconstriction, thereby increasing pulmonary wedge pressure. Inhaled nitric oxide can lower it. Moderate cardiac output and systematic arterial pressure are not affected; Selective in pulmonary because it is activated by hemoglobin; Selective vasodilation in the ventilated area, local hypoxia alveoli constricts the surrounding vascular tissue and redistributes blood flow to the ventilated lungs better and higher intraalveolar oxygen pressure. Inhaled nitric oxide enhances this mechanism by increasing blood flow through a well-ventilated lung; Bronchodilators; Pulmonary surfactant, The combination of high concentrations of inspired oxygen and high concentrations of Inhaled nitric oxide reduces the minimum surfactant surface tension.

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Journal Info

Abbrev

ijmp

Publisher

Subject

Engineering Health Professions Medicine & Pharmacology Public Health Veterinary

Description

Indonesian Journal of Medical Sciences and Public Health (IJMP) Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Subject areas include, but ...