<![CDATA[White turmeric (Curcuma zedoaria) is a herbal plant that is widely used as herbal medicine in Asia because of it’s properties which are believed to increase the body’s immune system, anti-inflammatory, and as analgesic. The use of herbal medicine is generally believed by the public to have lower side effects than modern medicine, but in reality, there has not been much research on the side effects of white turmeric usage. Therefore, this study aims to determine the acute toxicity of white turmeric’s rhizome ethanol extract on histopathological features of heart muscle. This experiment used 30 male white wistar rat (Rattus norvegicus) with weight between 150-200 grams. Rats were divided into 2 control groups and 4 groups of treatment. Treatment given to the rats are aquadest, NaCMC 1% WTE 250mg/KgBW, WTE 500mg/KgBW, WTE 750mg/KgBW, and WTE 2000mg/KgBW . The parameters observed are hyperemia, hemorrhage, and degeneration of heart muscle cell. The result showed in this study were that there were no mice that died due to EKP administration, but there was mild damage on WTE dose of 250 mg/KgBB, moderate damage on WTE dose of 500 mg/KgBB, moderate-severe damage on WTE dose of 750mg/KgBB and severe damage on WTE dose of 2000 mg/KgBW. Based on the results of this research, it can be concluded that there is significant damage found along with increasing dose of white turmeric extract given, where the damage on heart muscle cell is most severe at WTE dose of 2000 mg/KgBW.]]>
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