Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika
Vol 19, No 1 (2022): Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika

Analisis Graph Mining dalam Penentuan Senyawa Dan Tanaman Obat Indonesia Sebagai Antihipertensi

Lusi Agus Setiani (Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan, Jawa Barat, 16143, Indonesia)
Deden Ardiansyah (Unknown)
Asep Saepulrohman (Unknown)
Arief Rachman Hakim (Unknown)
Olandina Cahyani P (Unknown)



Article Info

Publish Date
15 Jul 2022

Abstract

Hypertension, also known as high blood pressure, is a degenerative disease whose prevalence tends to increase every year. People in Indonesia generally treat this disease by using a mixture of several types of herbal plants or so-called herbs. This study aims to find out the potential of compounds and plants that have effectiveness as antihypertensives by combining the concept of multicomponent-multi-target with a bioinformatics approach. This study aims to find out the potential of compounds and medicinal plants in Indonesia that have effectiveness as antihypertensives using graph mining analysis. Graph tracing techniques can be applied to search for compounds and plants related to target proteins in a disease. Patikan kebo (Euphorbia factor Ti2, betaAmyrin, alpha-Amyrin), mango (3-Carene, L-Histidine), cayenne pepper (Capsanthin, Capsorubin, Solasonine), papaya (L-Histidine, Sterol, Caffeine), and fenugreek ( L-Histidine) is the best plant that acts as an antihypertensive agent by targeting 4 proteins or about 80% of the total 5 significant proteins in hypertension.

Copyrights © 2022






Journal Info

Abbrev

komputasi

Publisher

Subject

Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management

Description

Scientific Journal of Computer and Mathematical Science (Jurnal Ilmiah Ilmu Komputer dan Matematika) is initiated and organized by Department of Computer Science, Faculty of Mathematics and Science, Pakuan University (Unpak), Bogor, Indonesia to accommodate the writing of research results for the ...