Jurnal Respirologi Indonesia
Vol 42, No 2 (2022)

The Relationship of Genetic Polymorphism Micromal Epoxide Hydrolase (EPHX1) His139Arg and Lung Cancer

Rosidah Hanum Hasibuan (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara)
Noni Novisari Soeroso (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara)
Setia Putra Tarigan (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara)
Yahwardiah Siregar (Department of Biomedical Science, Faculty of Medicine, University of Sumatera Utara)
Erna Mutiara (Department of Biostatistics, Faculty of Public Health, University of Sumatera Utara)
Lucia Aktalina (Department of Biomedical Science, Faculty of Medicine, University of Sumatera Utara)

Article Info

Publish Date
13 Apr 2022

Abstract

Background: Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in both activation and detoxification of polycyclic aromatic hydrocarbons (PAH) and aromatic amines. Polymorphism EPHX1 His139Arg in susceptibility to lung cancer has been reported with inconsistent outcomes. Aim of this study was to analyze the relationship between this polymorphism and lung cancer in smokers.Method: Consecutive sampling and case-control study was applied. Genotyping was performed by PCR-RFLP assay. The chi-square test with p<0.05 considered as significant.Results: Of all 84 subjects, in case and control groups, wild-type variant His139His were 34 (81%) and 30 (71.4%), heterozygote variant His139Arg were 8 (19%) and 12 (28.6%), there was no homozygote variant Arg139Arg identified. (p=0.36).Conclusion: The EPHX1 His139His represents a common polymorphism in both of subject groups. There is no association between His139Arg polymorphism of EPHX1 and lung cancer.

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Journal Info
Jurnal Respirologi Indonesia
Website

Abbrev

jri

Publisher

Perhimpunan Dokter Paru Indonesia

Subject

Health Professions Medicine & Pharmacology

Description

Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case ...