<![CDATA[ABSTRAKPendahuluan: Nyeri merupakan pengalaman sensorik dan emosional yang tidak menyenangkan akibat kerusakan jaringan. Senyawa metabolit sekunder flavonoid dan steroid ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) berfungsi sebagai analgesik dengan menghambat mediator-mediator inflamasi sehingga pelepasan asam arakidonat dan kerja enzim siklooksigenase terblokir. Tujuan penelitian menganalisis efek analgesik ekstrak daun Trembesi terhadap mencit putih (Mus musculus). Metode: Penelitian eksperimental laboratoris ini menggunakan teknik simple random sampling dengan sampel 30 ekor mencit dibagi menjadi 5 kelompok. Ekstrak daun trembesi yang digunakan dosis 25 mg/kgBB, 50 mg/kgBB, 100 mg/kgBB, kontrol negatif CMC.Na 0,5%, dan kontrol positif asetosal, pada masing-masing kelompok mencit putih jantan diberikan secara per oral, kemudian diinduksi nyeri dengan asam asetat 1% secara intraperitonial. Jumlah geliat mencit diamati setiap 5 menit selama 30 menit, lalu dihitung presentase efektivitas analgesiknya dengan membandingkan persentase proteksi analgesik kelompok senyawa uji terhadap persentase proteksi analgesik kelompok kontrol positif. Hasil: Ekstrak daun Trembesi dosis 100 mg/kgBB memberikan efek analgesik yang lebih besar yaitu 76,62% dibandingkan dengan ekstrak daun Trembesi dosis 25 mg/kgBB (24,63%) dan 50 mg/kgBB (49,34%). Nilai signifikansi hasil uji Kruskal Wallis sebesar 0,001 sehingga dapat diartikan terdapat perbedaan efektivitas analgesik ekstrak daun Trembesi yang signifikan antar kelompok. Simpulan: Terdapat efek analgesik ekstrak daun Trembesi (Samanea saman (Jacq.) Merr.) pada mencit putih (Mus musculus).Kata kunci: nyeri; analgesik; samanea saman, tikus putih ABSTRACTIntroduction: Pain is an sensory and emotional unpleasant experience because of tissue damage. Secondary metabolites of flavonoids and steroids from Trembesi (Samanea saman (Jacq.) Merr.) leaf extract have a function as analgesics by inhibiting inflammatory mediators so the release of arachidonic acid and the action of the cyclooxygenase enzyme is blocked. This study aimed to analyzed the analgesic effect of Trembesi leaf extract on white mice (Mus musculus). Methods: This experimental laboratory study used a simple random sampling technique with 30 mice samples divided into 5 groups. Trembesi leaf extract used was dose of 25 mg/kgBW, 50 mg/kgBW, 100 mg/kgBW, negative control CMC.Na 0.5%, and positive control Acetosal, given oral to each group, then induced pain with 1% acetic acid intraperitoneally. Number of stretching mice was observed every 5 minutes for 30 minutes, then the percentage of analgesic effectiveness was calculated by comparing the percentage of analgesic protection of the test group to the percentage of analgesic protection of the positive control group. Results: Trembesi leaf extract at a dose of 100 mg/kgBW gave a great analgesic effect, 76.62% compared to Trembesi leaf extract at a dose of 25 mg/kgBW (24.63%) and 50 mg/kgBW (49.34%). The significance value of the Kruskal Wallis test results is 0.001 so it can be interpreted that there is a significant difference in the analgesic effectiveness of Trembesi leaf extract between groups. Conclusion: There is an analgesic effect of Trembesi (Samanea saman (Jacq.) Merr.) leaf extract on white mice (Mus musculus).Keywords: pain; analgesic effect; saman leaf extract (samanea saman (jacq.) merr.); white mice ]]>
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