<![CDATA[Inflammation is a tissue response towards damaging physical or chemical stimulations. One local sign of inflammation is edema (tumor). Usage of natural herbal medicine has become an alternative way to prevent inflammation. The extract of umbi sarang semut (Myrmecodia tuberosa Jack) has anti-inflammation, anti-bacterial and antioxidant properties. This study is to determine the anti-inflammation effect of the topical application of Myrmecodia tuberosa Jack ethanol extract. This study used 28 white male rats previously induced with carragenin 2% b/v 0,5ml and divided into 4 treatment groups. Groups 1,2 dan 3 were given the ethanol extract with a concentration of 0,5 %; 1%; 2% respectively after induction and on 24, 48 and 72 hours after the first application. Group 4 was the untreated control group. Each treatment group were extracted for their inflammation exudate fluid from their backs using a 1 ml syringe. Edema fluid volume was measured. The results showed a decrease of edema fluid volume on all treatment groups. Statistical data analysis showed a significant difference between group 2 and the negative control; also between group 3 and the negative control. In conclusion, the topical ethanol extract of Myrmecodia tuberosa Jack can reduce inflammation reactions. Keywords: Myrmecodia tuberosa Jack, anti-inflammation, topical, edema fluid volume]]>
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