In Indonesia, Low Birth Weight (LBW) is the main cause of neonatal death. This study aims to determine the relationship between knowledge of pregnant women with low birth weight. This study was a cross-sectional on women who gave birth at the obstetrics and gynecology unit at the government-health service in Muna, Southeat Sulawesi. The sample size in this study was 108 people who were selected using a simple random sampling technique. The results of the study showed there was a relationship between knowledge of pregnant women and the incidence of low birth weight with P Value < 0.001 or p < = 0.05. Maternal knowledge about healthy preganancy, risk of LBW, and nutrition during pregnancy need to be considered in the prevention of LBW.
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