Acta Biochimica Indonesiana
Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana

Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India

Mohammad Zaid Kidwai (Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)
Roshan Alam (Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)
Haseeb Ahsan (Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India)
Mohammad Mustufa Khan (Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, India)
Saba Khan (Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India)

Article Info

Publish Date
31 Jul 2022

Abstract

Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity.Aim: The study was designed to determine the malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow.Method: The oxidative stress was analyzed in T2DM patients as MDA. The total antioxidant capacity was estimated through the FRAP in T2DM patients and control subjects.Results: The level of MDA was observed to be higher (4.84 ± 1.09) in T2DM patients compared to controls (2.20 ± 0.85). The FRAP was lower among T2DM patients (509.46 ± 126.36) compared to controls (895.62 ± 179.92). The difference between FRAP in T2DM patients and controls was statistically significant (p=0.0001).Conclusion: MDA was found to be higher in T2DM, and the FRAP level was lower in T2DM patients compared to controls, signifying increased oxidative stress and decreased antioxidant level in T2DM patients.

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Journal Info
Acta Biochimica Indonesiana
Website

Abbrev

actabioina

Publisher

Perhimpunan Biokimia dan Biologi Molekuler Indonesia

Subject

Biochemistry, Genetics & Molecular Biology

Description

Acta Biochimica Indonesiana (ActaBiolna) is a peer-reviewed and open-access journal that disseminates original research articles and review articles covering diverse topics in Biochemistry and Molecular Biology. The journal is published biannually by Indonesian Society for Biochemistry and Molecular ...