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All Journal Acta Biochimica Indonesiana
Mohammad Mustufa Khan
Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, India
Biochemistry, Genetics & Molecular Biology

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Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India Mohammad Zaid Kidwai; Roshan Alam; Haseeb Ahsan; Mohammad Mustufa Khan; Saba Khan
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.84

Abstract

Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity.Aim: The study was designed to determine the malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow.Method: The oxidative stress was analyzed in T2DM patients as MDA. The total antioxidant capacity was estimated through the FRAP in T2DM patients and control subjects.Results: The level of MDA was observed to be higher (4.84 ± 1.09) in T2DM patients compared to controls (2.20 ± 0.85). The FRAP was lower among T2DM patients (509.46 ± 126.36) compared to controls (895.62 ± 179.92). The difference between FRAP in T2DM patients and controls was statistically significant (p=0.0001).Conclusion: MDA was found to be higher in T2DM, and the FRAP level was lower in T2DM patients compared to controls, signifying increased oxidative stress and decreased antioxidant level in T2DM patients.
Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India Nabeela Usmani; Mukhtar Ahmad; Saba Khan; Mohammad Mustufa Khan; Haseeb Ahsan; Sadaf Parveen; Roshan Alam
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.141

Abstract

Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). Although it primarily affects the respiratory system, the virus may also target the pancreas. It was suggested that upregulation of angiotensin-converting enzyme II (ACE-II) cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 patients. Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury. Methods: A case control study was conducted in the Department of Biochemistry IIMS&R, Integral University, Lucknow. Two groups of subjects (70 adults consisting of 35 Covid-19 survivors and 35 controls) aged between 35 to 70 years were selected for the study with mild to moderate Covid-19 diagnosed using RT-PCR/rapid antigen test and a control group of healthy individuals without history of Covid-19. The serum amylase was determined by the direct substrate method and serum lipase by the turbidimetric UV method using a semi-autoanalyzer. Results: The study showed that the serum amylase (p=0.023) and lipase (p=0.002) levels were significantly elevated in Covid-19 patients compared to the control subjects. The findings indicated that Covid-19 patients had a substantially higher mean serum amylase and lipase levels than the control subjects. Conclusions: The Covid-19 patients are prone to pancreatic injury.
Co-Authors Haseeb Ahsan Mohammad Zaid Kidwai Mukhtar Ahmad Nabeela Usmani Roshan Alam Saba Khan Sadaf Parveen