Narra J
Vol. 2 No. 3 (2022): December 2022

Monkeypox: Immune response, vaccination and preventive efforts

Youdiil Ophinni (Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States
Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan)
Andri Frediansyah (PRTPP-National Research and Innovation Agency (BRIN), Yogyakarta, Indonesia)
Salin Sirinam (Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand)
Dewi Megawati (Department of Veterinary Pathobiology, School of Veterinary Medicine, University of Missouri, Columbia, MO, United States
Department of Microbiology and Parasitology, School of Medicine, Universitas Warmadewa, Bali, Indonesia)
Ana M. Stoian (Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, CA, United States)
Seyi S. Enitan (Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Nigeria)
Richard Y. Akele (Department of Biomedical Science, School of Applied Science, University Of Brighton, London, United Kingdom)
Ranjit Sah (Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal)
Krit Pongpirul (Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
Bumrungrad International Hospital, Bangkok, Thailand)
Ziad Abdeen (Department of Community Health, Faculty of Medicine, Al-Quds University, Jerusalem)
Sevda Aghayeva (Department of Gastroenterology, Baku Medical Plaza Hospital, Baku, Azerbaijan)
Aamer Ikram (National Institute of Heath, Islamabad, Pakistan)
Yohannes Kebede (Department of Health, Behavior and Society, Faculty of Public Health, Jimma University, Jimma, Ethiopia)
Uwe Wollina (Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany)
Kannan Subbaram (School of Medicine, The Maldives National University, Maldives)
Ai Koyanagi (Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Barcelona, Spain)
Abdulwahed Al Serouri (Yemen Field Epidemiology Training Program, Sana'a, Yemen)
H. Blaise Nguendo-Yongsi (Department of Epidemiology, School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon)
Jeffrey Edwards (Medical Research Foundation of Trinidad and Tobago, Port of Spain, Trinidad)
Dina E. Sallam (Department of Pediatrics and Pediatric Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt)
Yousef Khader (The Center of Excellence for Applied Epidemiology, The Eastern Mediterranean Public Health Network (EMPHNET), Amman, Jordan)
Sandro G. Viveiros-Rosa (National Institute of Industrial Property, Rio de Janeiro, Rio de Janeiro, Brazil)
Ziad A. Memish (Research & Innovation Centre, King Saud Medical City, Ministry of Health, Riyadh, Kingdom of Saudi Arabia
College of Medicine, AlFaisal University, Riyadh, Kingdom of Saudi Arabia)
Mehrdad Amir-Behghadami (Iranian Center of Excellence in Health Management, Department of Health Service Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran)
Sandro Vento (Faculty of Medicine, University of Puthisastra, Phnom Penh, Cambodia)
Marius Rademaker (Clinical Trial New Zealand, 218 Pembroke Street, Waikato Hospital Campus, Hamilton, New Zealand)
Malik Sallam (Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan
Department of Clinical Laboratories and Forensic Medicine, Jordan University Hospital, Amman, Jordan
Department of Translationa)

Article Info

Publish Date
14 Dec 2022

Abstract

Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.

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Journal Info
Narra J
Website

Abbrev

main

Publisher

PT Narra Sains Indonesia

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Narra J is a multidisciplinary journal and it is published three times (April, August, December) a year. The objective is to promote articles on infection, public health, global health, tropical infection, one health and diseases in tropics. Narra J publishes original research work across all ...