Medula
Vol 12 No 2 (2022): Medula

PERBEDAAN KADAR ASAM URAT TIKUS PUTIH (Rattus norvegicus) SETELAH PEMBERIAN KACANG TANAH (Arachis hypogaea L.)

Nabila Nuranjumi (Fakultas kedokteran, Universitas Lampung.)
agustyas tjiptaningrum (universitas lampung)
sofyan musyabiq (universitas lampung)
hanna mutiara (universitas lampung)



Article Info

Publish Date
11 Aug 2022

Abstract

The excessive uric acid levels in the body can increase the risk of hyperuricemia. The formation of uric acid starts from the synthesis of purines which produce inosine, adenine and guanine monophospate that will be degraded into uric acid. Peanuts contain purines so if it is consumed in excess, it can increase blood uric acid levels. To know the difference in the average blood uric acid levels of rats given peanuts at a dose of 1gr/200grBB, 2gr/200grBB, 4gr/200grBB and not given peanuts. This research used experimental research with post test control group design approach. The sample in this research used 28 rats that divided into 4 groups; K1 were only given standard feed, P1 were given 1gr / 200grBB peanuts, P2 were given 2gr/200grBB peanuts and P3 were given 4gr/200grBB peanuts in everyday for 28 days. Then measuring the blood uric acid levels of rats. The average blood uric acid level of rats before intervention (K1) is 3,28mg/dl, and after intervention is 3,87mg/dl (P1), 4,20mg/dl (P2) and 5,03mg/dl (P3). There is a significant difference between P2 and K1 (p=0,005 ), P3 and K1 (p=0,000 ). There is no a significant difference between P1 and K1 (p=0,130 ). There is a significant difference in the average blood uric acid level of rats given peanuts at a dose of 2gr/200grBB, 4gr/200grBB and not given peanuts. There is no significant difference in the average blood uric acid level of rats given peanuts at a dose of 1gr/200grBB and not given peanuts.

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Journal Info

Abbrev

medula

Publisher

Subject

Education Medicine & Pharmacology Neuroscience Public Health

Description

Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 ...