Jurnal Biosains Pascasarjana
Vol. 24 No. 1SP (2022): JURNAL BIOSAINS PASCASARJANA: SPECIAL ISSUE

EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8+ EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium

rian anggia destiawan (Universitas dr. Soebandi)
septyana eka rahmawati (Universitas Pendidikan Mandalika)
anas fadli wijaya (Universitas dr. Soebandi)
Ahdiah Imroatul Muflihah (Universitas dr. Soebandi)
Mutia Hariani Nurjanah (STIKES Karya Putra Bangsa Tulungagung)
Sholihatil hidayati (Universitas dr. Soebandi)
Ni Ketut Yuliana sari (poltekes Kemenkes Kupang)

Article Info

Publish Date
02 Jan 2023

Abstract

Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4+ expression. Black grape can boost the immune system through CD4+/CD8+ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4+ and CD8+ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 108 infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4+ and CD8+ is not different. Biologically, an increase in CD4+ and CD8+ expression at doses of 100 mg/KgBB. A decrease in CD4+ and CD8+ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4+ and CD8+ at low doses, as well as may decrease the expression of CD4+ and CD8+ at moderate to high doses.

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Journal Info
Jurnal Biosains Pascasarjana
Website

Abbrev

BIOPASCA

Publisher

Universitas Airlangga

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology

Description

Jurnal Biosains Pascasarjana is published not only for the publication of research results from graduates, as one of the graduation requirements but also for public that contains a discussion of the natural content, responses of living things, and their ...