Alchemy : Journal of Chemistry
Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry

Fabrication and Characterization of Ibuprofen and Ceftriaxone loaded Electrospun Cellulose Acetate Nanofiber Layers as a Model of Targeted Drug Delivery System

Novrynda Eko Satriawan (Institut Sains dan Teknologi Annuqayah)
Junaidi Khotib (Universitas Airlangga)
Muhamad Nasir (Badan Riset dan Inovasi Nasiona)
A. H. Zaidan (Universitas Airlangga)

Article Info

Publish Date
06 Jan 2023

Abstract

This study aims to study the process of fabricating and characterization nanofibers based on cellulose acetate polymer filled with ceftriaxone and ibuprofen using the electrospinning method as a model for a targeted drug delivery system. Cellulose acetate has been successfully fabricated into nanofibers using the electrospinning method and filled with ceftriaxone and ibuprofen. The resulting nanofibers have an average diameter in the range of 412.5 – 558.5 nm under the conditions of the electrospinning process, namely 22 kV voltage, 15 cm distance, and flow rate. 0.005 mL/min using acetone/DMAc (2:1). Based on the data generated from the FTIR test, homogeneity, and drug release test, it is known that the resulting nanofibers, namely cellulose acetate, cellulose acetate-ceftriaxone, and cellulose acetate-ibuprofen, have good morphological characteristics, homogeneity, and release rate so that they have the potential to be used as a targeted drug delivery system

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Journal Info
Alchemy : Journal of Chemistry
Website

Abbrev

Kimia

Publisher

Universitas Islam Negeri Maulana Malik Ibrahim Malang

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

Description

ALCHEMY: Journal of Chemistry (eISSN 2460-6871) is a scientific journal that focus on chemistry. This journal publishes a scientific article that cover research and review articles. Research topics for this journal such as natural science, physical chemistry, inorganic chemistry, organic chemistry, ...